Effects of selective serotonin reuptake inhibitors on DNA damage in patients with depression.
Adult
Case-Control Studies
Citalopram
/ administration & dosage
Comet Assay
DNA Damage
/ drug effects
DNA Glycosylases
/ genetics
Depressive Disorder
/ drug therapy
Female
Humans
Male
Middle Aged
Oxidative Stress
/ drug effects
Poly (ADP-Ribose) Polymerase-1
/ genetics
Selective Serotonin Reuptake Inhibitors
/ administration & dosage
Sertraline
/ administration & dosage
Citalopram
DNA damage
DNA repair
depression
sertraline
Journal
Journal of psychopharmacology (Oxford, England)
ISSN: 1461-7285
Titre abrégé: J Psychopharmacol
Pays: United States
ID NLM: 8907828
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
pubmed:
27
9
2019
medline:
24
7
2020
entrez:
27
9
2019
Statut:
ppublish
Résumé
The relationship between depression and increased oxidative stress is well known. DNA damage by oxidation factors is an important cause of the aging process in psychiatric disorders. Owing to the scarcity of human studies and high inconsistencies in studies of the effects of antidepressants on DNA damage, the current study was undertaken to investigate the effects of depression and its treatment on DNA damage. In a 15-week open-label study of citalopram ( DNA damage, 8-OHdG, IL-6 and expression of PARP1 were elevated in patients with depression compared with the healthy controls ( This is the first study on the effect of SSRIs on the DNA damage and some of the repair enzymes in depression. Based on the results, depression can cause increased DNA damage. This damage is followed by activation of compensatory mechanisms whereby the expression of DNA damage repair enzymes is elevated. Finally, the treatment of psychiatric disorder by antidepressants can lower the level of oxidative DNA damage.
Sections du résumé
BACKGROUND
The relationship between depression and increased oxidative stress is well known. DNA damage by oxidation factors is an important cause of the aging process in psychiatric disorders.
AIMS
Owing to the scarcity of human studies and high inconsistencies in studies of the effects of antidepressants on DNA damage, the current study was undertaken to investigate the effects of depression and its treatment on DNA damage.
METHODS
In a 15-week open-label study of citalopram (
RESULTS
DNA damage, 8-OHdG, IL-6 and expression of PARP1 were elevated in patients with depression compared with the healthy controls (
CONCLUSIONS
This is the first study on the effect of SSRIs on the DNA damage and some of the repair enzymes in depression. Based on the results, depression can cause increased DNA damage. This damage is followed by activation of compensatory mechanisms whereby the expression of DNA damage repair enzymes is elevated. Finally, the treatment of psychiatric disorder by antidepressants can lower the level of oxidative DNA damage.
Identifiants
pubmed: 31556787
doi: 10.1177/0269881119874461
doi:
Substances chimiques
Serotonin Uptake Inhibitors
0
Citalopram
0DHU5B8D6V
PARP1 protein, human
EC 2.4.2.30
Poly (ADP-Ribose) Polymerase-1
EC 2.4.2.30
DNA Glycosylases
EC 3.2.2.-
oxoguanine glycosylase 1, human
EC 3.2.2.-
Sertraline
QUC7NX6WMB
Types de publication
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM