In vitro transformation of primary human hepatocytes: Epigenetic changes and stemness properties.
Animals
Biomarkers, Tumor
/ genetics
Carcinoma, Hepatocellular
/ genetics
Cell Differentiation
/ genetics
Cell Line
Cell Line, Tumor
Cell Transformation, Neoplastic
/ genetics
Epigenesis, Genetic
/ genetics
Epithelial-Mesenchymal Transition
/ genetics
Female
HEK293 Cells
Hepatocytes
/ pathology
Humans
Liver Neoplasms
/ genetics
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplastic Stem Cells
/ pathology
Hepatocellular carcinoma
Immature phenotype
Primary human hepatocytes
Transformation
Journal
Experimental cell research
ISSN: 1090-2422
Titre abrégé: Exp Cell Res
Pays: United States
ID NLM: 0373226
Informations de publication
Date de publication:
15 11 2019
15 11 2019
Historique:
received:
02
04
2019
revised:
19
09
2019
accepted:
21
09
2019
pubmed:
27
9
2019
medline:
17
6
2020
entrez:
27
9
2019
Statut:
ppublish
Résumé
Human hepatocarcinogenesis is a complex process with many unresolved issues, including the cell of origin (differentiated and/or progenitor/stem cells) and the initial steps leading to tumor development. With the aim of providing new tools for studying hepatocellular carcinoma initiation and progression, we developed an innovative model based on primary human hepatocytes (PHHs) lentivirus-transduced with SV40
Identifiants
pubmed: 31557464
pii: S0014-4827(19)30510-5
doi: 10.1016/j.yexcr.2019.111643
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
111643Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.