Airway obstruction in young adults born extremely preterm or extremely low birth weight in the postsurfactant era.
Adult
Aging
/ physiology
Airway Obstruction
/ physiopathology
Birth Weight
/ physiology
Bronchopulmonary Dysplasia
/ physiopathology
Case-Control Studies
Female
Follow-Up Studies
Forced Expiratory Volume
/ physiology
Gestational Age
Humans
Infant, Extremely Low Birth Weight
/ physiology
Infant, Extremely Premature
/ physiology
Infant, Newborn
Male
Premature Birth
/ physiopathology
Pulmonary Surfactants
/ therapeutic use
Pulmonary Ventilation
/ physiology
Vital Capacity
/ physiology
COPD epidemiology
Paediatric Lung Disaese
Journal
Thorax
ISSN: 1468-3296
Titre abrégé: Thorax
Pays: England
ID NLM: 0417353
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
27
06
2019
revised:
05
08
2019
accepted:
30
08
2019
pubmed:
29
9
2019
medline:
27
5
2020
entrez:
28
9
2019
Statut:
ppublish
Résumé
It is unknown if adults born <28 weeks or <1000 g since surfactant has been available are reaching their full airway growth potential. To compare expiratory airflow at 25 years and from 8 to 25 years of participants born <28 weeks or <1000 g with controls, and within the preterm group to compare those who had bronchopulmonary dysplasia with those who did not. All survivors born <28 weeks or <1000 g in 1991-1992 in Victoria, Australia, were eligible. Controls were born contemporaneously, weighing >2499 g. At 8, 18 and 25 years, expiratory airflows were measured and the results converted to z-scores. Outcomes were compared between groups at age 25 years, and trajectories (change in z-scores per year) from childhood were contrasted between groups. Expiratory airflows were measured at 25 years on 164 of 297 (55%) preterm survivors and 130 of 260 (50%) controls. Preterm participants had substantially reduced airflow compared with controls at age 25 years (eg, zFEV Young adults born <28 weeks or <1000 g in the surfactant era, particularly those who had bronchopulmonary dysplasia, have substantially reduced airway function compared with controls. Some are destined to develop COPD in later adult life.
Sections du résumé
BACKGROUND
It is unknown if adults born <28 weeks or <1000 g since surfactant has been available are reaching their full airway growth potential.
OBJECTIVE
To compare expiratory airflow at 25 years and from 8 to 25 years of participants born <28 weeks or <1000 g with controls, and within the preterm group to compare those who had bronchopulmonary dysplasia with those who did not.
METHODS
All survivors born <28 weeks or <1000 g in 1991-1992 in Victoria, Australia, were eligible. Controls were born contemporaneously, weighing >2499 g. At 8, 18 and 25 years, expiratory airflows were measured and the results converted to z-scores. Outcomes were compared between groups at age 25 years, and trajectories (change in z-scores per year) from childhood were contrasted between groups.
RESULTS
Expiratory airflows were measured at 25 years on 164 of 297 (55%) preterm survivors and 130 of 260 (50%) controls. Preterm participants had substantially reduced airflow compared with controls at age 25 years (eg, zFEV
CONCLUSIONS
Young adults born <28 weeks or <1000 g in the surfactant era, particularly those who had bronchopulmonary dysplasia, have substantially reduced airway function compared with controls. Some are destined to develop COPD in later adult life.
Identifiants
pubmed: 31558625
pii: thoraxjnl-2019-213757
doi: 10.1136/thoraxjnl-2019-213757
doi:
Substances chimiques
Pulmonary Surfactants
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1147-1153Informations de copyright
© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.