Possible role of L-form switching in recurrent urinary tract infection.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
26 09 2019
26 09 2019
Historique:
received:
13
05
2019
accepted:
28
08
2019
entrez:
28
9
2019
pubmed:
29
9
2019
medline:
7
1
2020
Statut:
epublish
Résumé
Recurrent urinary tract infection (rUTI) is a major medical problem, especially in the elderly and infirm, but the nature of the reservoir of organisms responsible for survival and recolonisation after antibiotic treatment in humans is unclear. Here, we demonstrate the presence of cell-wall deficient (L-form) bacteria in fresh urine from 29 out of 30 older patients with rUTI. In urine, E. coli strains from patient samples readily transition from the walled state to L-form during challenge with a cell wall targeting antibiotic. Following antibiotic withdrawal, they then efficiently transition back to the walled state. E. coli switches between walled and L-form states in a zebrafish larva infection model. The results suggest that L-form switching is a physiologically relevant phenomenon that may contribute to the recurrence of infection in older patients with rUTI, and potentially other infections.
Identifiants
pubmed: 31558767
doi: 10.1038/s41467-019-12359-3
pii: 10.1038/s41467-019-12359-3
pmc: PMC6763468
doi:
Substances chimiques
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4379Subventions
Organisme : Wellcome Trust
ID : 206444/Z/17/Z
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
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