Neurosteroids and neuropathic pain management: Basic evidence and therapeutic perspectives.

Chronic Pain / drug therapy Humans Neuralgia / drug therapy Neuroprotection / physiology Neurosteroids / metabolism Nociception / drug effects Pain Management
Chronic pain Neuroactive steroid Neuroprotection Neurosteroid Nociception Peripheral neuropathy

Journal

Frontiers in neuroendocrinology
ISSN: 1095-6808
Titre abrégé: Front Neuroendocrinol
Pays: United States
ID NLM: 7513292

Informations de publication

Date de publication:
10 2019
Historique:
received: 22 07 2019
revised: 17 09 2019
accepted: 24 09 2019
pubmed: 29 9 2019
medline: 11 4 2020
entrez: 29 9 2019
Statut: ppublish

Résumé

Complex mechanisms involved in neuropathic pain that represents a major health concern make its management complicated. Because neurosteroids are bioactive steroids endogenously synthesized in the nervous system, including in pain pathways, they appear relevant to develop effective treatments against neuropathic pain. Neurosteroids act in paracrine or autocrine manner through genomic mechanisms and/or via membrane receptors of neurotransmitters that pivotally modulate pain sensation. Basic studies which uncovered a direct link between neuropathic pain symptoms and endogenous neurosteroid production/regulation, paved the way for the investigations of neurosteroid therapeutic potential against pathological pain. Concordantly, antinociceptive properties of synthetic neurosteroids were evidenced in humans and animals. Neurosteroids promote peripheral analgesia mediated by T-type calcium and gamma-aminobutyric acid type A channels, counteract chemotherapy-induced neuropathic pain and ameliorate neuropathic symptoms of injured spinal cord animals by stimulating anti-inflammatory, remyelinating and neuroprotective processes. Together, these data open interesting perspectives for neurosteroid-based strategies to manage/alleviate efficiently neuropathic pain.

Identifiants

DOI: 10.1016/j.yfrne.2019.100795 PMID: 31562849
pubmed: 31562849
pii: S0091-3022(19)30057-3
doi: 10.1016/j.yfrne.2019.100795
pii:
doi:

Substances chimiques

Neurosteroids 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

100795

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Laurence Meyer (L)

Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Bâtiment 3 de la Faculté de Médecine, 11 Rue Humann, 67 000 Strasbourg, France.

Omar Taleb (O)

Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Bâtiment 3 de la Faculté de Médecine, 11 Rue Humann, 67 000 Strasbourg, France.

Christine Patte-Mensah (C)

Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Bâtiment 3 de la Faculté de Médecine, 11 Rue Humann, 67 000 Strasbourg, France.

Ayikoe-Guy Mensah-Nyagan (AG)

Biopathologie de la Myéline, Neuroprotection et Stratégies Thérapeutiques, INSERM U1119, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Bâtiment 3 de la Faculté de Médecine, 11 Rue Humann, 67 000 Strasbourg, France. Electronic address: gmensah@unistra.fr.

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Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Douleur chronique › Neurosteroids and neuropathic pain management:...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Neurosteroids and neuropathic pain management:...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Névralgie › Neurosteroids and neuropathic pain management:...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neuroprotection › Neurosteroids and neuropathic pain management:...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Neurostéroïdes › Neurosteroids and neuropathic pain management:...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Perception › Perception de la douleur › Nociception › Neurosteroids and neuropathic pain management:...
questionsmedicales.fr › Administration des services de santé › Gestion des soins aux patients › Prise en charge de la maladie › Gestion de la douleur › Neurosteroids and neuropathic pain management:...