Diffuse Midline Glioma With Osseous Metastases at Diagnosis: A Case Report.
Journal
Journal of pediatric hematology/oncology
ISSN: 1536-3678
Titre abrégé: J Pediatr Hematol Oncol
Pays: United States
ID NLM: 9505928
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
pubmed:
1
10
2019
medline:
1
1
2021
entrez:
1
10
2019
Statut:
ppublish
Résumé
Extraneural metastasis is extremely rare in pediatric patients with high-grade glioma and carries a grim prognosis. Detection of metastases at initial presentation is even rarer. A 15-year-old adolescent girl presented with paraplegia, urinary retention, and a constellation of systemic symptoms. Imaging showed a fourth ventricular lesion, innumerable intradural lesions, leptomeningeal seeding throughout the neuraxis, and numerous osteoblastic lesions involving the spine, ribs, sternum, pelvis, humerus, and femurs. Pathology confirmed metastatic diffuse midline glioma, H3K27M-mutant. Our patient died 2 weeks after initial presentation. Further work is needed to develop effective treatment strategies for these high-risk patients.
Identifiants
pubmed: 31568066
doi: 10.1097/MPH.0000000000001598
pii: 00043426-202010000-00039
doi:
Substances chimiques
Histones
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e673-e676Références
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