Antifungals in a case of basidiobolomycosis: role and limitations.
paediatrics
unwanted effects/adverse reactions
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
30 Sep 2019
30 Sep 2019
Historique:
entrez:
2
10
2019
pubmed:
2
10
2019
medline:
29
2
2020
Statut:
epublish
Résumé
A 10-year-old Saudi boy was diagnosed to have basidiobolomycosis after a stormy course of his ailment. Therapy was initiated with intravenous antifungal, voriconazole, which was well tolerated for 6 weeks except for local excoriation at the site of ileostomy. He developed drug-induced hepatitis on oral voriconazole, therefore, switched to oral itraconazole following which he experienced severe chest pain. Alternatively, co-trimoxazole (bactrim) an antibacterial with antifungal activity was prescribed but he had the intolerance to it as well. Unfortunately, posaconazole as an alternative antifungal was not available in our centre. We report here a Saudi boy who developed an intolerance to most common antifungals used clinically 6 weeks after the therapy was initiated.
Identifiants
pubmed: 31570348
pii: 12/9/e230206
doi: 10.1136/bcr-2019-230206
pmc: PMC6768487
pii:
doi:
Substances chimiques
Antifungal Agents
0
Itraconazole
304NUG5GF4
Voriconazole
JFU09I87TR
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Med Mycol Case Rep. 2012 Nov 15;2:11-4
pubmed: 24432205
Medicine (Baltimore). 2015 Sep;94(35):e1430
pubmed: 26334903
J Med Microbiol. 2012 Dec;61(Pt 12):1770-1774
pubmed: 22918871
J Trop Pediatr. 2014 Dec;60(6):476-9
pubmed: 25213739
Iran J Med Sci. 2012 Jun;37(2):134-6
pubmed: 23115443
Iran Red Crescent Med J. 2014 Aug 17;16(9):e14109
pubmed: 25593711
Curr Drug Saf. 2018;13(1):59-61
pubmed: 28971777
Ann Saudi Med. 2013 Sep-Oct;33(5):500-4
pubmed: 24188947
J Coll Physicians Surg Pak. 2017 Aug;27(8):508-510
pubmed: 28903846