Serotonin transport in the 21st century.
Journal
The Journal of general physiology
ISSN: 1540-7748
Titre abrégé: J Gen Physiol
Pays: United States
ID NLM: 2985110R
Informations de publication
Date de publication:
04 11 2019
04 11 2019
Historique:
received:
21
05
2019
accepted:
24
08
2019
pubmed:
2
10
2019
medline:
5
9
2020
entrez:
2
10
2019
Statut:
ppublish
Résumé
Serotonin (5-hydroxytryptamine [5-HT]) is accumulated within nerve endings by the serotonin transporter (SERT), which terminates its extracellular action and provides cytoplasmic 5-HT for refilling of synaptic vesicles. SERT is the target for many antidepressant medications as well as psychostimulants such as cocaine and ecstasy (3,4-methylenedioxymethamphetamine). SERT belongs to the SLC6 family of ion-coupled transporters and is structurally related to several other transporter families. SERT was studied in the 1970s and 1980s using membrane vesicles isolated from blood platelets. These studies led to a proposed stoichiometry of transport that has been challenged by high-resolution structures of SERT and its homologues and by studies of SERT electrophysiology. Here, we review the original evidence alongside more recent structural and electrophysiological evidence. A self-consistent picture emerges with surprising insights into the ion fluxes that accompany 5-HT transport.
Identifiants
pubmed: 31570504
pii: jgp.201812066
doi: 10.1085/jgp.201812066
pmc: PMC6829555
doi:
Substances chimiques
Serotonin Plasma Membrane Transport Proteins
0
Serotonin
333DO1RDJY
Banques de données
PDB
['3TT1', '2A65', '3TT3', '3DH4', '6DZZ', '5I6X']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1248-1264Subventions
Organisme : Austrian Science Fund FWF
ID : P 31813
Pays : Austria
Organisme : NINDS NIH HHS
ID : R01 NS102277
Pays : United States
Informations de copyright
© 2019 Rudnick and Sandtner.
Références
Nat Commun. 2018 Jan 15;9(1):230
pubmed: 29335402
Biophys J. 2015 Mar 24;108(6):1390-1399
pubmed: 25809252
J Neurosci. 2000 Apr 15;20(8):2749-57
pubmed: 10751425
J Biol Chem. 2006 Nov 24;281(47):36213-20
pubmed: 17008313
Proteins. 2014 Oct;82(10):2797-811
pubmed: 25043943
Nature. 2019 May;569(7754):141-145
pubmed: 31019304
Nat Struct Mol Biol. 2014 Nov;21(11):1006-12
pubmed: 25282149
Biochemistry. 1978 Sep 19;17(19):3949-53
pubmed: 708689
Neuron. 2003 Oct 30;40(3):537-49
pubmed: 14642278
J Biol Chem. 1982 Jun 10;257(11):6151-5
pubmed: 7076668
J Neurosci. 1997 Feb 1;17(3):960-74
pubmed: 8994051
Biochim Biophys Acta. 1972 Aug 4;265(3):367-416
pubmed: 4581579
Scand J Haematol Suppl. 1969;8:3-26
pubmed: 4242950
Science. 2008 Dec 12;322(5908):1655-61
pubmed: 19074341
Nature. 2005 Sep 8;437(7056):215-23
pubmed: 16041361
Proc Natl Acad Sci U S A. 1976 Jun;73(6):1892-6
pubmed: 6961
J Biol Chem. 2012 Jan 2;287(1):438-45
pubmed: 22072712
Nature. 2009 Mar 5;458(7234):47-52
pubmed: 19262666
Br J Pharmacol. 2014 Feb;171(4):1007-18
pubmed: 24251585
Pflugers Arch. 2014 Jan;466(1):25-42
pubmed: 24337881
Annu Rev Biophys. 2015;44:311-37
pubmed: 26098517
Biophys J. 1996 Dec;71(6):3126-35
pubmed: 8968583
Science. 1990 Sep 14;249(4974):1303-6
pubmed: 1975955
J Neurochem. 1998 Nov;71(5):2211-9
pubmed: 9798949
J Am Chem Soc. 2008 Mar 26;130(12):3853-65
pubmed: 18314975
J Exp Biol. 2006 Dec;209(Pt 24):4858-68
pubmed: 17142674
Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1786-E1795
pubmed: 28223522
J Biol Chem. 1995 Nov 10;270(45):27099-105
pubmed: 7592962
Mol Pharmacol. 1993 Feb;43(2):271-6
pubmed: 8429828
Biochemistry. 1983 Mar 1;22(5):1236-41
pubmed: 6838850
Biochim Biophys Acta. 1970 Aug 4;216(1):13-21
pubmed: 4250571
J Biol Chem. 2008 Jun 20;283(25):17691-701
pubmed: 18426798
J Biol Chem. 1979 Oct 25;254(20):10084-9
pubmed: 489585
Mol Pharmacol. 1993 Dec;44(6):1227-31
pubmed: 7903417
Biochemistry. 1978 Oct 31;17(22):4739-42
pubmed: 728383
Nature. 2011 Jun 2;474(7349):109-13
pubmed: 21516104
Br J Pharmacol. 1969 Nov;37(3):680-8
pubmed: 5348470
Nature. 2013 Nov 7;503(7474):85-90
pubmed: 24037379
Science. 2008 Oct 31;322(5902):709-13
pubmed: 18927357
J Neurochem. 1978 Jul;31(1):251-6
pubmed: 27588
Neuropharmacology. 2005 Nov;49(6):811-9
pubmed: 16185723
Nature. 1991 Nov 7;354(6348):66-70
pubmed: 1944572
J Biol Chem. 1996 Mar 22;271(12):6911-6
pubmed: 8636118
Eur J Biochem. 1979 Mar 15;95(1):1-20
pubmed: 378655
PLoS One. 2019 Jun 28;14(6):e0217377
pubmed: 31251747
J Biol Chem. 1983 May 25;258(10):6115-9
pubmed: 6853478
Science. 2010 Apr 23;328(5977):470-3
pubmed: 20413494
Annu Rev Biophys. 2013;42:95-120
pubmed: 23451896
Biochemistry. 1978 Apr 4;17(7):1207-11
pubmed: 656383
J Biol Chem. 1970 Dec 10;245(23):6357-65
pubmed: 5484815
Nature. 1991 Mar 28;350(6316):350-4
pubmed: 2008212
Mol Pharmacol. 1994 Apr;45(4):608-17
pubmed: 8183239
Proc Natl Acad Sci U S A. 1974 Feb;71(2):484-8
pubmed: 4521818
Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1817-21
pubmed: 1347426
Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10338-43
pubmed: 18647834
FEBS Lett. 1992 Jun 29;305(2):110-4
pubmed: 1618338
J Biol Chem. 2013 Feb 15;288(7):4549-56
pubmed: 23288838
Nature. 2016 Apr 21;532(7599):334-9
pubmed: 27049939
Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8854-E8862
pubmed: 30181291
Acta Physiol Scand. 1971 Jan;81(1):75-83
pubmed: 5543317
Neuron. 1992 May;8(5):927-35
pubmed: 1534013
J Gen Physiol. 2018 Mar 5;150(3):431-451
pubmed: 29439119
Nat Struct Mol Biol. 2007 May;14(5):365-71
pubmed: 17435767
J Biol Chem. 2003 Apr 11;278(15):12703-9
pubmed: 12569103
Science. 1991 Oct 25;254(5031):579-80
pubmed: 1948036
J Neurochem. 1990 Jul;55(1):260-7
pubmed: 2355221
Cell Tissue Res. 2011 Nov;346(2):151-61
pubmed: 22006250
J Biol Chem. 1982 Feb 10;257(3):1172-6
pubmed: 7056713
Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9
pubmed: 26546518
Neurochem Res. 2010 Apr;35(4):628-35
pubmed: 20041293
Neuron. 2000 Feb;25(2):373-83
pubmed: 10719892
Biophys J. 2002 Dec;83(6):3268-82
pubmed: 12496095
FEBS Lett. 1991 Dec 16;295(1-3):149-54
pubmed: 1765147
Nat Commun. 2019 Apr 11;10(1):1687
pubmed: 30976000
Biochemistry. 1992 Jul 28;31(29):6710-8
pubmed: 1322169
J Biol Chem. 1977 Apr 10;252(7):2170-4
pubmed: 849926
J Neurosci. 1999 Jun 15;19(12):4705-17
pubmed: 10366604
J Biol Chem. 2007 Oct 5;282(40):29441-7
pubmed: 17698848
Neuron. 1994 Apr;12(4):845-59
pubmed: 8161456
Proc Natl Acad Sci U S A. 2012 Oct 30;109(44):E3035-44
pubmed: 23047697
Biochem Pharmacol. 1992 May 28;43(10):2189-99
pubmed: 1599505
J Physiol. 2014 Mar 1;592(5):863-9
pubmed: 23878376
Biochim Biophys Acta. 1965 Nov 29;109(2):467-77
pubmed: 5867548
Nature. 2012 Jan 09;481(7382):469-74
pubmed: 22230955
Biophys J. 2003 Sep;85(3):1548-59
pubmed: 12944272
J Biol Chem. 1979 Jun 10;254(11):4631-5
pubmed: 438209
J Biol Chem. 2016 Dec 9;291(50):25864-25876
pubmed: 27756841
Pharmacol Rev. 2011 Sep;63(3):585-640
pubmed: 21752877
J Biol Chem. 2016 Jan 15;291(3):1456-71
pubmed: 26582198
Science. 2008 Aug 8;321(5890):810-4
pubmed: 18599740
FEBS Lett. 1969 Apr;3(2):103-106
pubmed: 11946980
J Biol Chem. 2015 Jan 2;290(1):544-55
pubmed: 25381247
Biochemistry. 1994 Aug 9;33(31):9118-25
pubmed: 8049215
Physiology (Bethesda). 2009 Dec;24:377-86
pubmed: 19996368
Nature. 2010 May 13;465(7295):188-93
pubmed: 20463731
Mol Cell. 2008 Jun 20;30(6):667-77
pubmed: 18570870
Prog Neurobiol. 1973;1(2):151-98
pubmed: 4273118
Neuron. 1993 Feb;10(2):177-88
pubmed: 7679914
Biophys J. 2012 Sep 5;103(5):878-88
pubmed: 23009837
Nat Chem Biol. 2010 Feb;6(2):109-16
pubmed: 20081826
J Biol Chem. 2006 Sep 8;281(36):26444-54
pubmed: 16798738