A conjugative plasmid that augments virulence in Klebsiella pneumoniae.
Animals
Anti-Bacterial Agents
/ pharmacology
Carbapenems
/ pharmacology
Drug Resistance, Multiple, Bacterial
/ genetics
Genome, Bacterial
Klebsiella Infections
/ microbiology
Klebsiella pneumoniae
/ drug effects
Larva
/ microbiology
Male
Mice
Moths
/ microbiology
Plasmids
/ genetics
Virulence
/ genetics
Journal
Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
27
03
2019
accepted:
19
08
2019
pubmed:
2
10
2019
medline:
8
7
2020
entrez:
2
10
2019
Statut:
ppublish
Résumé
A virulence-encoding plasmid, p15WZ-82_Vir, which formed as a result of the integration of a 100-kb fragment of the hypervirulence plasmid pLVPK into a conjugative IncFIB plasmid, was recovered from a clinical Klebsiella variicola strain. Such a plasmid could be conjugated to carbapenem-resistant Klebsiella strains, enabling them to simultaneously express the carbapenem resistance- and hypervirulence-associated phenotypes. Unlike the non-conjugative pLVPK plasmid, emergence of p15WZ-82_Vir may promote rapid dissemination of virulence-encoding elements among Gram-negative bacterial pathogens.
Identifiants
pubmed: 31570866
doi: 10.1038/s41564-019-0566-7
pii: 10.1038/s41564-019-0566-7
doi:
Substances chimiques
Anti-Bacterial Agents
0
Carbapenems
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2039-2043Références
Paczosa, M. K. & Mecsas, J. Microbiol. Mol. Biol. Rev. 80, 629–661 (2016).
doi: 10.1128/MMBR.00078-15
Shon, A. S. & Russo, T. A. Future Microbiol. 7, 669–671 (2012).
doi: 10.2217/fmb.12.43
Zhang, Y. et al. J. Infect. 71, 553–560 (2015).
doi: 10.1016/j.jinf.2015.07.010
Li, W. et al. Clin. Infect. Dis. 58, 225–232 (2014).
doi: 10.1093/cid/cit675
Gu, D. et al. Lancet Infect. Dis. 18, 37–46 (2018).
doi: 10.1016/S1473-3099(17)30489-9
Hopkins, K. L. et al. J. Antimicrob. Chemother. 72, 2129–2131 (2017).
doi: 10.1093/jac/dkx103
Zurfluh, K., Poirel, L., Nordmann, P., Klumpp, J. & Stephan, R. Antimicrob. Resist. Infect. Control 4, 38 (2015).
doi: 10.1186/s13756-015-0080-5
Diancourt, L., Passet, V., Verhoef, J., Grimont, P. A. & Brisse, S. J. Clin. Microbiol. 43, 4178–4182 (2005).
doi: 10.1128/JCM.43.8.4178-4182.2005
Brisse, S. et al. J. Clin. Microbiol. 51, 4073–4078 (2013).
doi: 10.1128/JCM.01924-13
Chen, Y. T. et al. Gene 337, 189–198 (2004).
doi: 10.1016/j.gene.2004.05.008
Taylor, D. E. et al. J. Bacteriol. 184, 4690–4698 (2002).
doi: 10.1128/JB.184.17.4690-4698.2002
Weinstein, M. P. M100 Performance Standards for Antimicrobial Susceptibility Testing (Clinical and Laboratory Standards Institute, 2018).
Wick, R. R., Judd, L. M., Gorrie, C. L. & Holt, K. E. PLoS Comput. Biol. 13, e1005595 (2017).
doi: 10.1371/journal.pcbi.1005595
Brettin, T. et al. Sci. Rep. 5, 8365 (2015).
doi: 10.1038/srep08365
Seemann, T. Bioinformatics 30, 2068–2069 (2014).
doi: 10.1093/bioinformatics/btu153
Wyres, K. L. et al. Microb. Genom. 2, e000102 (2016).
pubmed: 28348840
pmcid: 5359410
Alikhan, N. F., Petty, N. K., Ben Zakour, N. L. & Beatson, S. A. BMC Genomics 12, 402 (2011).
doi: 10.1186/1471-2164-12-402
Sullivan, M. J., Petty, N. K. & Beatson, S. A. Bioinformatics 27, 1009–1010 (2011).
doi: 10.1093/bioinformatics/btr039
Huang, Y. et al. Antimicrob. Agents Chemother. 60, 4364–4368 (2016).
doi: 10.1128/AAC.00859-16
McLaughlin, M. M. et al. BMC Infect. Dis. 14, 31 (2014).
doi: 10.1186/1471-2334-14-31
Zhang, R. et al. Antimicrob. Agents Chemother. 60, 709–711 (2016).
doi: 10.1128/AAC.02173-15
Palacios, M. et al. mBio 9, e01443-18 (2018).
doi: 10.1128/mBio.01443-18
Shon, A. S., Bajwa, R. P. & Russo, T. A. Virulence 4, 107–118 (2013).
doi: 10.4161/viru.22718