Neuropharmacological effects of d-pinitol and its possible mechanisms of action.
Animals
Anti-Anxiety Agents
/ pharmacology
Anticonvulsants
/ pharmacology
Antidepressive Agents
/ pharmacology
Flumazenil
/ adverse effects
Hypnotics and Sedatives
/ pharmacology
Inositol
/ analogs & derivatives
Mice
Mice, Inbred BALB C
Neuropharmacology
Pentylenetetrazole
/ adverse effects
Seizures
/ chemically induced
Yohimbine
/ adverse effects
anticonvulsant
antidepressant-like
anxiolytic-like
d-pinitol
Journal
Journal of food biochemistry
ISSN: 1745-4514
Titre abrégé: J Food Biochem
Pays: United States
ID NLM: 7706045
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
30
07
2019
revised:
11
09
2019
accepted:
16
09
2019
pubmed:
3
10
2019
medline:
29
9
2020
entrez:
3
10
2019
Statut:
ppublish
Résumé
The aim was to evaluate the diuretic and neuropharmacological actions of d-pinitol and describe a possible mechanism of action. The diuretic effects of d-pinitol were evaluated using mice placed in metabolic cages. The sedative, anxiolytic-like, antidepressant-like, and anticonvulsant effects of 1-100 mg/kg d-pinitol were assessed. The possible mechanisms of action of the anxiolytic-like, antidepressant-like, and anticonvulsant effects of d-pinitol were evaluated using inhibitors. d-pinitol lacked diuretic effects. However, d-pinitol showed the highest anxiolytic-like actions (ED
Substances chimiques
Anti-Anxiety Agents
0
Anticonvulsants
0
Antidepressive Agents
0
Hypnotics and Sedatives
0
Yohimbine
2Y49VWD90Q
Flumazenil
40P7XK9392
pinitol
484-68-4
Inositol
4L6452S749
Pentylenetetrazole
WM5Z385K7T
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13070Informations de copyright
© 2019 Wiley Periodicals, Inc.
Références
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