Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation.
GSTO1-1
IL-1β
NEK7
NLRP3 inflammasome
deglutathionylation
glutathione
pyroptosis
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
01 10 2019
01 10 2019
Historique:
received:
20
09
2018
revised:
31
07
2019
accepted:
23
08
2019
entrez:
3
10
2019
pubmed:
3
10
2019
medline:
18
9
2020
Statut:
ppublish
Résumé
The NLRP3 inflammasome is a cytosolic complex sensing phagocytosed material and various damage-associated molecular patterns, triggering production of the pro-inflammatory cytokines interleukin-1 beta (IL)-1β and IL-18 and promoting pyroptosis. Here, we characterize glutathione transferase omega 1-1 (GSTO1-1), a constitutive deglutathionylating enzyme, as a regulator of the NLRP3 inflammasome. Using a small molecule inhibitor of GSTO1-1 termed C1-27, endogenous GSTO1-1 knockdown, and GSTO1-1
Identifiants
pubmed: 31577945
pii: S2211-1247(19)31127-1
doi: 10.1016/j.celrep.2019.08.072
pii:
doi:
Substances chimiques
Cytokines
0
Inflammasomes
0
Inflammation Mediators
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
NLRP3 protein, human
0
GSTO1 protein, human
EC 2.5.1.18
Glutathione Transferase
EC 2.5.1.18
NEK7 protein, human
EC 2.7.11.1
NIMA-Related Kinases
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
151-161.e5Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.