Anti-Inflammatory Effects of HDL (High-Density Lipoprotein) in Macrophages Predominate Over Proinflammatory Effects in Atherosclerotic Plaques.
Animals
Aorta, Thoracic
/ metabolism
Carrier Proteins
/ biosynthesis
Cells, Cultured
Disease Models, Animal
Female
Flow Cytometry
Gene Expression Regulation
Immunoblotting
Inflammation
/ genetics
Lipoproteins, HDL
/ pharmacology
Macrophages
/ metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Plaque, Atherosclerotic
/ genetics
Recombinant Proteins
cholesterol
high-density lipoprotein
inflammation
macrophages
rHDL infusion
Journal
Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
pubmed:
4
10
2019
medline:
14
4
2020
entrez:
4
10
2019
Statut:
ppublish
Résumé
HDL (high-density lipoprotein) infusion reduces atherosclerosis in animal models and is being evaluated as a treatment in humans. Studies have shown either anti- or proinflammatory effects of HDL in macrophages, and there is no consensus on the underlying mechanisms. Here, we interrogate the effects of HDL on inflammatory gene expression in macrophages. Approach and Results: We cultured bone marrow-derived macrophages, treated them with reconstituted HDL or HDL isolated from Reconstituted HDL infusions in hypercholesterolemic atherosclerotic mice produced anti-inflammatory effects in lesion macrophages suggesting a beneficial therapeutic effect of HDL in vivo.
Identifiants
pubmed: 31578081
doi: 10.1161/ATVBAHA.119.313253
pmc: PMC6879856
mid: NIHMS1540588
doi:
Substances chimiques
Carrier Proteins
0
Lipoproteins, HDL
0
Recombinant Proteins
0
TLR4-associated protein, mouse
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e253-e272Subventions
Organisme : NCRR NIH HHS
ID : S10 RR027050
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL107653
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL126028
Pays : United States
Organisme : NIDDK NIH HHS
ID : DP3 DK108209
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL127694
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL092969
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK017047
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
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