Obesity and childhood asthma in male schoolchildren in Saudi Arabia: Is there a role for leptin, interleukin-4, interleukin-5, and interleukin-21?
Journal
Annals of Saudi medicine
ISSN: 0975-4466
Titre abrégé: Ann Saudi Med
Pays: Saudi Arabia
ID NLM: 8507355
Informations de publication
Date de publication:
Historique:
entrez:
4
10
2019
pubmed:
4
10
2019
medline:
23
2
2020
Statut:
ppublish
Résumé
Adiposity is associated with high serum levels of adipokines and chemokines which are possibly implicated in a co-existence of obesity and asthma. Elucidate the possible roles of leptin, interleukin (IL)-4, IL-5 and IL-21 in linking obesity with childhood asthma. Cross-sectional, analytical. Population of schoolchildren in a small Saudi city. The study included a representative sample of Saudi schoolchildren grouped as obese asthmatics, non-obese asthmatics, or obese nonasthmatics, with nonobese nonasthmatics as a control group. An asthma control test was done for the asthmatic groups. Serum levels of leptin, IL-4, IL-5, and IL-21. 345 male schoolchildren with a mean (SD) age of 13.0 (2.3) years. Median serum leptin concentrations in obese asthmatics were significantly higher than in nonobese asthmatics ( P<.001). Uncontrolled asthmatics also had significantly higher leptin levels than controlled asthmatic children ( P<.002). Leptin levels were weakly but significantly correlated with the cytokines IL-4, IL-5, and IL-21. Leptin may contribute to a link between obesity and childhood asthma. Differences in IL-21 levels between nonobese and obese asthmatics suggest that the co-existence of asthma and obesity increased IL-21 levels. Leptin plus some proinflammatory cytokines especially IL-21 may be potential predictors for asthma control in children. Blood sampling at different stages of asthma might influence cytokine expression. None.
Sections du résumé
BACKGROUND
BACKGROUND
Adiposity is associated with high serum levels of adipokines and chemokines which are possibly implicated in a co-existence of obesity and asthma.
OBJECTIVES
OBJECTIVE
Elucidate the possible roles of leptin, interleukin (IL)-4, IL-5 and IL-21 in linking obesity with childhood asthma.
DESIGN
METHODS
Cross-sectional, analytical.
SETTING
METHODS
Population of schoolchildren in a small Saudi city.
SUBJECTS AND METHODS
METHODS
The study included a representative sample of Saudi schoolchildren grouped as obese asthmatics, non-obese asthmatics, or obese nonasthmatics, with nonobese nonasthmatics as a control group. An asthma control test was done for the asthmatic groups.
MAIN OUTCOME MEASURES
METHODS
Serum levels of leptin, IL-4, IL-5, and IL-21.
SAMPLE SIZE
METHODS
345 male schoolchildren with a mean (SD) age of 13.0 (2.3) years.
RESULTS
RESULTS
Median serum leptin concentrations in obese asthmatics were significantly higher than in nonobese asthmatics ( P<.001). Uncontrolled asthmatics also had significantly higher leptin levels than controlled asthmatic children ( P<.002). Leptin levels were weakly but significantly correlated with the cytokines IL-4, IL-5, and IL-21.
CONCLUSIONS
CONCLUSIONS
Leptin may contribute to a link between obesity and childhood asthma. Differences in IL-21 levels between nonobese and obese asthmatics suggest that the co-existence of asthma and obesity increased IL-21 levels. Leptin plus some proinflammatory cytokines especially IL-21 may be potential predictors for asthma control in children.
LIMITATIONS
CONCLUSIONS
Blood sampling at different stages of asthma might influence cytokine expression.
CONFLICT OF INTEREST
BACKGROUND
None.
Identifiants
pubmed: 31580718
doi: 10.5144/0256-4947.2019.295
pmc: PMC6832322
doi:
Substances chimiques
IL4 protein, human
0
IL5 protein, human
0
Interleukin-5
0
Interleukins
0
Leptin
0
Interleukin-4
207137-56-2
interleukin-21
MKM3CA6LT1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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