Mutational Analysis and Modeling of Negative Allosteric Modulator Binding Sites in AMPA Receptors.

Allosteric Regulation / drug effects Animals Binding Sites / drug effects Crystallography, X-Ray Female HEK293 Cells Humans Mutation / genetics Nitriles Protein Structure, Secondary Pyridones / pharmacology Receptors, Glutamate / chemistry Xenopus laevis

Journal

Molecular pharmacology
ISSN: 1521-0111
Titre abrégé: Mol Pharmacol
Pays: United States
ID NLM: 0035623

Informations de publication

Date de publication:
12 2019
Historique:
received: 30 04 2019
accepted: 01 10 2019
pubmed: 5 10 2019
medline: 4 3 2020
entrez: 5 10 2019
Statut: ppublish

Résumé

The

Identifiants

DOI: 10.1124/mol.119.116871 PMID: 31582576
pubmed: 31582576
pii: mol.119.116871
doi: 10.1124/mol.119.116871
doi:

Substances chimiques

Nitriles 0
Pyridones 0
Receptors, Glutamate 0
alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype glutamate receptor, human 0
perampanel H821664NPK

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

835-850

Informations de copyright

Copyright © 2019 by The American Society for Pharmacology and Experimental Therapeutics.

Auteurs

Charlotte Stenum-Berg (C)

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (C.S.-B., S.C.-A., C.L.T., L.B., A.S.K.); and Department of Biochemistry, University of Oxford, Oxford, United Kingdom (M.M., P.C.B.).

Maria Musgaard (M)

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (C.S.-B., S.C.-A., C.L.T., L.B., A.S.K.); and Department of Biochemistry, University of Oxford, Oxford, United Kingdom (M.M., P.C.B.).

Sergei Chavez-Abiega (S)

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (C.S.-B., S.C.-A., C.L.T., L.B., A.S.K.); and Department of Biochemistry, University of Oxford, Oxford, United Kingdom (M.M., P.C.B.).

Christine L Thisted (CL)

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (C.S.-B., S.C.-A., C.L.T., L.B., A.S.K.); and Department of Biochemistry, University of Oxford, Oxford, United Kingdom (M.M., P.C.B.).

Lorenzo Barrella (L)

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (C.S.-B., S.C.-A., C.L.T., L.B., A.S.K.); and Department of Biochemistry, University of Oxford, Oxford, United Kingdom (M.M., P.C.B.).

Philip C Biggin (PC)

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (C.S.-B., S.C.-A., C.L.T., L.B., A.S.K.); and Department of Biochemistry, University of Oxford, Oxford, United Kingdom (M.M., P.C.B.).

Anders S Kristensen (AS)

Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark (C.S.-B., S.C.-A., C.L.T., L.B., A.S.K.); and Department of Biochemistry, University of Oxford, Oxford, United Kingdom (M.M., P.C.B.) ask@sund.ku.dk.

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Régulation allostérique › Mutational Analysis and Modeling of Negative...
questionsmedicales.fr › Eucaryotes › Animaux › Mutational Analysis and Modeling of Negative...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Mutational Analysis and Modeling of Negative...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Cristallographie aux rayons X › Mutational Analysis and Modeling of Negative...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Mutational Analysis and Modeling of Negative...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mutational Analysis and Modeling of Negative...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutational Analysis and Modeling of Negative...
questionsmedicales.fr › Composés chimiques organiques › Nitriles › Mutational Analysis and Modeling of Negative...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure secondaire des protéines › Mutational Analysis and Modeling of Negative...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Pyridones › Mutational Analysis and Modeling of Negative...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs au glutamate › Mutational Analysis and Modeling of Negative...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Amphibiens › Anura › Pipidae › Xenopus › Xenopus laevis › Mutational Analysis and Modeling of Negative...