Role of MafB in macrophages.
MafB
homeostasis
large Maf family
macrophage
transcription factor
Journal
Experimental animals
ISSN: 1881-7122
Titre abrégé: Exp Anim
Pays: Japan
ID NLM: 9604830
Informations de publication
Date de publication:
29 Jan 2020
29 Jan 2020
Historique:
pubmed:
5
10
2019
medline:
21
4
2020
entrez:
5
10
2019
Statut:
ppublish
Résumé
The transcription factor MafB regulates macrophage differentiation. However, studies on the phenotype of Mafb-deficient macrophages are still limited. Recently, it was shown that the specific expression of MafB permits macrophages to be distinguished from dendritic cells. In addition, MafB has been reported to be involved in various diseases related to macrophages. Studies using macrophage-specific Mafb-deficient mice show that MafB is linked to atherosclerosis, autoimmunity, obesity, and ischemic stroke, all of which exhibit macrophage abnormality. Therefore, MafB is hypothesized to be indispensable for the regulation of macrophages to maintain systemic homeostasis and may serve as an innovative target for treating macrophage-related diseases.
Identifiants
pubmed: 31582643
doi: 10.1538/expanim.19-0076
pmc: PMC7004803
doi:
Substances chimiques
MAFB protein, human
0
MafB Transcription Factor
0
Mafb protein, mouse
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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