The Obesity Paradox in Pulmonary Rehabilitation: Relevance and Implications to Clinical Practice.


Journal

Journal of cardiopulmonary rehabilitation and prevention
ISSN: 1932-751X
Titre abrégé: J Cardiopulm Rehabil Prev
Pays: United States
ID NLM: 101291247

Informations de publication

Date de publication:
01 Nov 2024
Historique:
medline: 1 11 2024
pubmed: 1 11 2024
entrez: 1 11 2024
Statut: ppublish

Résumé

Pulmonary rehabilitation (PR) increases exercise capacity, reduces dyspnea, and improves quality of life (QoL) in patients with chronic obstructive pulmonary disease (COPD). Patients requiring PR can present with multiple comorbidities. One of the most common comorbidities is obesity. The prevalence of obesity in patients with COPD is increasing at an alarming rate. To date the efficacy of PR to ameliorate obesity in patients with COPD is unclear. Obesity in patients with COPD is associated with increased morbidity and mortality compared to patients without obesity. However, the benefits of obesity paradox in lower mortality rate health-related QoL and health care utilization remain unclear. This review discusses the challenges of prescribing PR to patients with obesity and COPD. In addition, the definition of and the potential challenges and benefits of the obesity paradox in patients with COPD will be discussed. Treatment strategies that include combining PR with lifestyle management, individually tailored nutritional advice, pharmacotherapy, and surgery need to be tested in prospective, randomized controlled trials. The challenges of providing complex care, prioritizing patient needs, and future directions will also be discussed for patients with obesity and COPD.

Identifiants

pubmed: 39485895
doi: 10.1097/HCR.0000000000000913
pii: 01273116-202411000-00008
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

417-424

Informations de copyright

Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

Déclaration de conflit d'intérêts

The authors declare no conflicts of interest.

Références

GBD 2019 Risk Factor Collaborators. Global Burden of 87 Risk Factors in 204 Countries and Territories, 1990–2019: a systematic analysis for the global burden of disease study 2019. Lancet. 2020;396(10258):1223-1249. doi:10.1016/S0140-6736(20)30752-2.
doi: 10.1016/S0140-6736(20)30752-2
Adeloye D, Song P, Zhu Y, Campbell H, Sheikh A, Rudan I. Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling analysis. Lancet Respir Med. 2022;10(5):447-458. doi:10.1016/S2213-2600(21)00511-7.
doi: 10.1016/S2213-2600(21)00511-7
World Health Organization (WHO). The top ten causes of death. WHO website. Published December 9, 2020. Accessed March 28th, 2024. https://www.who.int/news-room/fact-sheets/detail/the-top-10-causes-of-death
World Health Organization. Obesity and overweight. Accessed 22 March, 2024. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
Global BMI Mortality Collaboration. Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents. Lancet. 2016;388(10046):776-786. doi:10.1016/S0140-6736(16)30175-1.
doi: 10.1016/S0140-6736(16)30175-1
Ward ZJ, Bleich SN, Cradock AL, et al. Projected US State-level prevalence of adult obesity and severe obesity. N Engl J Med. 2019;381(25):2440-2450. doi:10.1056/NEJMsa1909301.
doi: 10.1056/NEJMsa1909301
Opio J, Wynne K, Attia J, et al. Overweight or obesity increases the risk of cardiovascular disease among older Australian adults, even in the absence of cardiometabolic risk factors: a Bayesian survival analysis from the Hunter Community Study. Int J Obes (Lond). 2023;47(2):117-125. doi:10.1038/s41366-022-01241-w.
doi: 10.1038/s41366-022-01241-w
Larsson SC, Burgess S. Causal role of high body mass index in multiple chronic diseases: a systematic review and meta-analysis of Mendelian randomization studies. BMC Med. 2021;19(1):320. doi:10.1186/s12916-021-02188-x.
doi: 10.1186/s12916-021-02188-x
Tzenois N, Tazanios ME, Chahine M. The impact of BMI on breast cancer- an updated systematic review and meta-analysis. Medicine (Baltimore). 2024;103(5):e36831. doi:10.1097/MD.0000000000036831.
doi: 10.1097/MD.0000000000036831
Maurer J, Rebbapragada V, Borson S, et al. Anxiety and depression in COPD: current understanding, unanswered questions and research needs. Chest. 2008;134(4 Suppl):43S-56S. doi:10.1378/chest.08-0342.
doi: 10.1378/chest.08-0342
Sode BF, Dahl M, Nordestgaard BG. Myocardial infarction and other co-morbidities in patients with chronic obstructive pulmonary disease: a Danish nationwide study of 7.4 million individuals. Eur Heart J. 2011;32(19):2365-2375. doi:10.1093/eurheartj/ehr338.
doi: 10.1093/eurheartj/ehr338
Yohannes AM, Chen W, Moga AM, Leroi I, Connolly MJ. Cognitive impairment in chronic obstructive pulmonary disease and chronic heart failure a systematic review and meta-analysis of observational studies. J Am Med Dir Assoc. 2017;18(5):45.e1-451.e11. doi:10.1016/j.jamda.2017.01.014.
doi: 10.1016/j.jamda.2017.01.014
Park SS, Perez JLP, Gandara BP, et al. Mechanisms linking COPD to Type 1 and 2 diabetes mellitus: is there a relationship between diabetes and COPD? Medicina (Kauna). 2022;58(8):1030. doi:10.3390/medicina58081030.
doi: 10.3390/medicina58081030
Piras O, Travaglino F, Autunno A, et al. Chronic systemic inflammatory syndrome in patients with AECOPD presenting to emergency department. Eur Rev Med Pharmacol Sci. 2012;16(16 Suppl):57-61.
Yohannes AM, Mulerova H, Lavoie K, et al. The association of depressive symptoms with rates of acute exacerbations in patients with COPD: results from a 3-year longitudinal follow-up of the ECLIPSE cohort. J Am Med Dir Assoc. 2017;18(11):955-959. doi:10.1016/j.jamda.2017.05.024.
doi: 10.1016/j.jamda.2017.05.024
Centers for Disease Control and Prevention. Defining adult overweight and obesity. 2022. Accessed March 24, 2024. https://www.cdc.gov/obesity/basics/adult-defining.html
Wouters EFM. Obesity and metabolic abnormalities in chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2017;14(Suppl. 5):S389-S394. doi:10.1513/AnnalsATS.201705-371AW.
doi: 10.1513/AnnalsATS.201705-371AW
Putcha N, Anzueto AR, Calverley PMA, et al. Mortality and exacerbation risk by body mass index in patients with COPD in TIOSPIR and UPLIFT. Ann Am Thorac Soc. 2022;19(2):204-213. doi:10.1513/AnnalsATS.202006-722OC.
doi: 10.1513/AnnalsATS.202006-722OC
Landbo C, Prescott E, Lange P, Vestbo J, Almdal TP. Prognostic value of nutritional status in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1999;160(6):1856-1861. doi:10.1164/ajrccm.160.6.9902115.
doi: 10.1164/ajrccm.160.6.9902115
Rodriguez DA, Garcia-Aymerich J, Valera JL, et al. Determinants of exercise capacity in obese and non-obese COPD patients. Respir Med. 2014;9(8):e105220.
Lambert AA, Putcha N, Drummond MB, et al. Obesity is associated with increased morbidity in moderate to severe COPD. Chest. 2017;151(1):168-177. doi:10.1016/j.chest.2016.08.1432.
doi: 10.1016/j.chest.2016.08.1432
Cao C, Wang R, Wang I, Bunjhoo H, Xu Y, Xiong W. Body mass index and mortality in chronic obstructive pulmonary disease: a meta-analysis. PLoS ONE. 2012;7(8):e43892. doi:10.1371/journal.pone.0043892.
doi: 10.1371/journal.pone.0043892
Yamauchi Y, Hasegawa W, Yasunaga H, et al. Paradoxical association between body mass index and in-hospital mortality in elderly patients with chronic obstructive pulmonary disease in Japan. Int J COPD. 2014;9:1337-1346. doi:10.2147/COPD.S75175.
doi: 10.2147/COPD.S75175
Simati S, Kokkinos A, Dalamaga M, Argyrakopoulos G. Obesity paradox: fact or fiction? Curr Obes Rep. 2023;12(2):75-85. doi:10.1007/s13679-023-00497-1.
doi: 10.1007/s13679-023-00497-1
Eisner MD, Blanc PD, Sidney S, et al. Body composition and functional limitation in COPD. Respir Res. 2007;8(1):7. doi:10.1186/1465-9921-8-7.
doi: 10.1186/1465-9921-8-7
Fabbri LM, Celli BR, Agustí A, et al. COPD and multimorbidity: recognising and addressing a syndemic occurrence. Lancet Respir Med. 2023;11(11):1020-1034. doi:10.1016/S2213-2600(23)00261-8.
doi: 10.1016/S2213-2600(23)00261-8
Vivodtzev I, Monocharmont L, Tamiser R, et al. Quadriceps muscle fat infiltration is associated with cardiometabolic risk in COPD. Cline Physiol Funct Imaging. 2018;38(5):788-797. doi:10.1111/cpf.12481.
doi: 10.1111/cpf.12481
Leme ACB, Ferrari G, Fisberg RM, et al. Co-occurrence and clustering of sedentary behaviours, diet, sugar-sweetened beverages, and alcohol intake among adults: the Latin American Nutrition and Health Study (ELANS). Nutrients. 2021;13(6):1809. doi:10.3390/nu13061809.
doi: 10.3390/nu13061809
Jessri M, Wolfinger RD, Lou WY. Identification of dietary patterns associated with obesity in a nationally representative survey of Canadian adults: application of a priori, hybrid, and simplified dietary pattern techniques. Am J Clin Nutr. 2017;105(3):669-684. doi:10.3945/ajcn.116.134684.
doi: 10.3945/ajcn.116.134684
Spetlta F, Pasini AMF, Cazzoletti L, Ferrari M. Body weight and mortality in COPD: focus on obesity paradox. Eat Weight Diord. 2018;23(1):15-22. doi:10.1007/s40519-017-0456-z.
doi: 10.1007/s40519-017-0456-z
Katz P, Iribarren C, Sanchez G, Blanc BD. Obesity and functioning among individuals with chronic obstructive pulmonary disease (COPD). COPD. 2016;13(3):352-359. doi:10.3109/15412555.2015.1087991.
doi: 10.3109/15412555.2015.1087991
Alqarni AA, Badr OI, Aldhahir AM, et al. Obesity prevalence and association with spirometry profiles, ICU admission, and comorbidities among patients with COPD: retrospective study in two territary centres in Saudi Arabia. Int J Chron Obstruct Pulmon Dis. 2024;19:111-120. doi:10.2147/COPD.S442851.
doi: 10.2147/COPD.S442851
Goto T, Hirayama A, Faridi MK, Camargo CA, Hasegwa K. Obesity and severity of acute exacerbation of chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2018;15(2):184-191.
Owusu-Bediako K, Pfaff K, Tram NK, et al. Association of severe obesity and chronic obstructive pulmonary disease with pneumonia following non-cardiac surgery. J Clin Med Res. 2022;14(6):237-243. doi:10.14740/jocmr4741.
doi: 10.14740/jocmr4741
Smulders L, Aalst AV, Edet N, et al. Decreased risk of COPD exacerbation in obese patients. COPD. 2020;17(5):485-491. doi:10.1080/15412555.2020.1799963.
doi: 10.1080/15412555.2020.1799963
Ades PA, Savage PD. The obesity paradox: perception vs knowledge. Mayo Clin Proc. 2010;85(2):112-114. doi:10.4065/mcp.2009.0777.
doi: 10.4065/mcp.2009.0777
Vestbo J, Prescott E, Almdal T, et al. Body mass, fat-free body mass, and prognosis in patients with chronic obstructive pulmonary disease from a random population sample findings from the Copenhagen city heart study. Am J Respir Crit Care Med. 2006;173(1):79-83. doi:10.1164/rccm.200506-969OC.
doi: 10.1164/rccm.200506-969OC
Rochester CL, Alison JA, Carlin B, et al., on behalf of the American Thoracic Society Assembly on Pulmonary Rehabilitation. Am J Respir Crit Care Med. 2023;208(4):e7-e26. doi:10.1164/rccm.202306-1066ST.
doi: 10.1164/rccm.202306-1066ST
Machado FVE, Spurit MA, Groenen MTJ, et al. Frequency and functional translation of low muscle mass in overweight and obese patients with COPD. Respir Res. 2021;22(1):93. doi:10.1186/s12931-021-01689-w.
doi: 10.1186/s12931-021-01689-w
Ercin DOZ, Alkan H, Findikoglu G, Dursunoglu N, Evyapan F, Ardic F. Interval versus continuous aerobic exercise training in overweight and obese patients with chronic obstructive pulmonary disease: a randomized controlled trial. J Cardiopulm Rehabil Prev. 2020;40(4):268-275. doi:10.1097/HCR.0000000000000519.
doi: 10.1097/HCR.0000000000000519
Au DH, Gleason E, Hunter-Mill B, et al. Lifestyle intervention and excess weight in chronic obstructive pulmonary disease (COPD): INSIGHT COPD randomized clinical trial. Ann Am Thorac Soc. 2023;20(12):1743-1751. doi:10.1513/AnnalsATS.202305-458OC.
doi: 10.1513/AnnalsATS.202305-458OC
Greening NJ, Evans RA, Weilliams JEA, Green RH, Singh SJ, Steiner MC. Does body mass index influence the outcomes of a walking-based pulmonary rehabilitation programme in COPD? Chronic Respir Dis. 2012;9(2):99-106. doi:10.1177/1479972312439317.
doi: 10.1177/1479972312439317
Huber MB, Schneider N, Kirsch F, Schwarzkopf L, Schramm A, Leidi R. Long-term weight gain in obese COPD patients participating in a disease management program: a risk factor for reduced health-related quality of life. Respir Res. 2021;22(1):226. doi:10.1186/s12931-021-01787-9.
doi: 10.1186/s12931-021-01787-9
Brauwers B, Machado FVC, RJHC B, Spruit MA, Franssen FME. Combined exercise training and nutritional interventions or pharmacological treatments to improve exercise capacity and body composition in chronic obstructive pulmonary disease: a narrative review. Nutrients. 2023;15(24):5136. doi:10.3390/nu15245136.
doi: 10.3390/nu15245136
Jenkins AC, Gaynor-sodeifi K, Lewithwaite H, et al. Efficacy of interventions to alter measures of fat-free mass in people with COPD: a systematic review and meta-analysis. ERJ Open Res. 2023;9(4):00102-2023. doi:10.1183/23120541.00102-2023.
doi: 10.1183/23120541.00102-2023
Yohannes AM, Connolly MJ. Pulmonary rehabilitation programmes in the UK: a national representative survey. Clin Rehabil. 2004;18(4):444-449. doi:10.1191/0269215504cr736oa.
doi: 10.1191/0269215504cr736oa
Tunsupon P, Mador MJ. The influence of body composition on pulmonary rehabilitation outcomes in chronic obstructive pulmonary disease patients. Lung. 2017;195(6):729-738. doi:10.1007/s00408-017-0053-y.
doi: 10.1007/s00408-017-0053-y
Lipovec NC, RJHC B, Borst BVD, Doehner W, Lainscak M, Schols AMW. The prevalence of metabolic syndrome in chronic obstructive pulmonary disease: a systematic review. COPD. 2016;13(3):399-406. doi:10.3109/15412555.2016.1140732.
doi: 10.3109/15412555.2016.1140732
Maatman RC, Spruit MA, van Melick PP, et al. Effect of obesity on weight-bearing versus weight supported exercise testing in patients with COPD. Respirology. 2016;21(3):483-488. doi:10.1111/resp.12700.
doi: 10.1111/resp.12700
O’Donnell DE, Ciavaglia CE, Neder JA. When obesity and chronic obstructive pulmonary disease collide. Physiological and clinical consequences. Ann Am Thorac Soc. 2014;11(4):635-644. doi:10.1513/AnnalsATS.201312-438FR.
doi: 10.1513/AnnalsATS.201312-438FR
Cleven L, Krell-Roesch J, Nigg CR, Woll A. The association between physical activity with incident obesity, coronary heart disease, diabetes and hypertension in adults: a systematic review of longitudinal studies published after 2012. BMC Public Health. 2020;20(1):726. doi:10.1186/s12889-020-08715-4.
doi: 10.1186/s12889-020-08715-4
Yohannes AM. The paradox of obesity in patients with chronic obstructive pulmonary disease. Ann Thorac ATS. 2022;19(10):1638-1639. doi:10.1513/AnnalsATS.202206-525ED.
doi: 10.1513/AnnalsATS.202206-525ED
Yohannes AM, Stone RA, Lowe D, Pursey NA, Buckingham RJ, Roberts CM. Pulmonary rehabilitation in the United Kingdom. Chron Respir Dis. 2011;8(3):193-199. doi:10.1177/1479972311413400.
doi: 10.1177/1479972311413400
Laddu D, Neeland IJ, Camethon M, et al., on behalf of the American Heart Association Obesity Committee of the Council on Lifestyle and Cardiometabolic Health; Council on Epidemiology and Prevention; Council on Clinical Cardiology; Council on Hypertension; Council on the Kidney in Cardiovascular Disease; and Council on Cardiovascular and Stroke Nursing. Implementation of obesity science into clinical practice: a scientific statement from the American Heart Association. Circulation. 2024;150(1):e7-e19. doi:10.1161/CIR.0000000000001221.
doi: 10.1161/CIR.0000000000001221
Chittal P, Babu AS, Lavie CJ. Obesity paradox: does fat alter outcomes in chronic obstructive pulmonary disease. COPD. 2015;12(1):14-18. doi:10.3109/15412555.2014.915934.
doi: 10.3109/15412555.2014.915934
Cordero AIH, Sin DD. Why is BMI related to COPD? Is it all in the genes. Am J Respir Crit Care Med . Published April 09, 2024 (in press). doi:10.1164/rccm.202403-0601ED.
doi: 10.1164/rccm.202403-0601ED
Wan ES, Polak M, Goldstein RL, et al. Physical activity, exercise capacity, and body composition in US Veterans with chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2022;19(10):1669-1676. doi:10.1513/AnnalsATS.202111-1221OC.
doi: 10.1513/AnnalsATS.202111-1221OC
Divo MJ, Marin JM, Casanova CC, et al., BODE Collaborative group. Comorbidities and mortality risk in adults younger than 50 years of age with chronic obstructive pulmonary disease. Respir Res. 2022;23(1):267. doi:10.1186/s12931-022-02191-7.
doi: 10.1186/s12931-022-02191-7

Auteurs

Abebaw M Yohannes (AM)

Author Affiliations: Department of Physical Therapy, School of Health Professions, University of Alabama at Birmingham, (Dr Yohannes); and Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama (Drs Yohannes, Dransfield, and Morris).

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