Theranostics Targeting Fibroblast Activation Protein in the Tumor Stroma:
Actinium
Animals
Cell Line, Tumor
Cell Transformation, Neoplastic
Copper Radioisotopes
Endopeptidases
Gelatinases
/ metabolism
Humans
Isotope Labeling
Male
Membrane Proteins
/ metabolism
Mice
Mice, Nude
Molecular Targeted Therapy
Pancreatic Neoplasms
/ diagnostic imaging
Positron-Emission Tomography
Radiopharmaceuticals
/ chemistry
Serine Endopeptidases
/ metabolism
Tissue Distribution
actinium
fibroblast activation protein
pancreatic cancer
theranostics
α-therapy
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
pubmed:
6
10
2019
medline:
29
9
2020
entrez:
6
10
2019
Statut:
ppublish
Résumé
Fibroblast activation protein (FAP), which promotes tumor growth and progression, is overexpressed in cancer-associated fibroblasts of many human epithelial cancers. Because of its low expression in normal organs, FAP is an excellent target for theranostics. In this study, we used radionuclides with relatively long half-lives,
Identifiants
pubmed: 31586001
pii: jnumed.119.233122
doi: 10.2967/jnumed.119.233122
pmc: PMC7198371
doi:
Substances chimiques
Actinium-225
0
Copper Radioisotopes
0
Copper-64
0
Membrane Proteins
0
Radiopharmaceuticals
0
Endopeptidases
EC 3.4.-
Serine Endopeptidases
EC 3.4.21.-
fibroblast activation protein alpha
EC 3.4.21.-
Gelatinases
EC 3.4.24.-
Actinium
NIK1K0956U
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
563-569Informations de copyright
© 2020 by the Society of Nuclear Medicine and Molecular Imaging.
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