First-in-Humans Imaging with
89Zr-IAB22M2C PET
CD8+ T cell
lung cancer
melanoma
minibody
Journal
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
ISSN: 1535-5667
Titre abrégé: J Nucl Med
Pays: United States
ID NLM: 0217410
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
08
05
2019
accepted:
21
08
2019
pubmed:
6
10
2019
medline:
29
9
2020
entrez:
6
10
2019
Statut:
ppublish
Résumé
Immunotherapy is becoming the mainstay for treatment of a variety of malignancies, but only a subset of patients responds to treatment. Tumor-infiltrating CD8-positive (CD8+) T lymphocytes play a central role in antitumor immune responses. Noninvasive imaging of CD8+ T cells may provide new insights into the mechanisms of immunotherapy and potentially predict treatment response. We are studying the safety and utility of
Identifiants
pubmed: 31586002
pii: jnumed.119.229781
doi: 10.2967/jnumed.119.229781
pmc: PMC7198374
doi:
Substances chimiques
CD8 Antigens
0
Immunoconjugates
0
Radioisotopes
0
Zirconium
C6V6S92N3C
Zirconium-89
NTM296JU95
Types de publication
Clinical Trial, Phase I
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
512-519Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
© 2020 by the Society of Nuclear Medicine and Molecular Imaging.
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