Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields.
Animals
Antibodies, Monoclonal
/ chemistry
Antibodies, Neutralizing
/ chemistry
CD4 Antigens
/ metabolism
Cells, Cultured
Crystallization
Crystallography, X-Ray
Disease Models, Animal
Glycosylation
HIV
/ physiology
HIV Antibodies
/ immunology
HIV Envelope Protein gp120
/ metabolism
HIV Infections
/ immunology
Humans
Macaca mulatta
Membrane Glycoproteins
/ metabolism
Polysaccharides
/ chemistry
Protein Binding
Simian Acquired Immunodeficiency Syndrome
/ immunology
Simian Immunodeficiency Virus
/ physiology
Structure-Activity Relationship
Viral Envelope Proteins
/ metabolism
CD4 receptor
HIV-1
SIVmac239
broadly neutralizing antibody
co-crystal structure
glycan hole
glycan recognition
glycan shield
gp120
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
15 10 2019
15 10 2019
Historique:
received:
03
12
2018
revised:
20
06
2019
accepted:
11
09
2019
pubmed:
7
10
2019
medline:
18
2
2020
entrez:
7
10
2019
Statut:
ppublish
Résumé
HIV- and SIV-envelope (Env) trimers are both extensively glycosylated, and antibodies identified to date have been unable to fully neutralize SIV
Identifiants
pubmed: 31586542
pii: S1074-7613(19)30403-0
doi: 10.1016/j.immuni.2019.09.007
pii:
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Neutralizing
0
CD4 Antigens
0
HIV Antibodies
0
HIV Envelope Protein gp120
0
Membrane Glycoproteins
0
Polysaccharides
0
Viral Envelope Proteins
0
gp120 protein, Simian immunodeficiency virus
0
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
724-734.e4Informations de copyright
Published by Elsevier Inc.