The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by methylene violet 3RAX.

Acetylcholinesterase / chemistry Butyrylcholinesterase / chemistry Cholinesterase Inhibitors / chemistry Humans Kinetics Phenothiazines / chemistry
Acetylcholinesterase Butyrylcholinesterase Cholinesterase inhibition Methylene violet 3RAX

Journal

Chemico-biological interactions
ISSN: 1872-7786
Titre abrégé: Chem Biol Interact
Pays: Ireland
ID NLM: 0227276

Informations de publication

Date de publication:
01 Dec 2019
Historique:
received: 02 07 2019
revised: 26 09 2019
accepted: 04 10 2019
pubmed: 9 10 2019
medline: 15 11 2019
entrez: 9 10 2019
Statut: ppublish

Résumé

Phenazines, naturally produced by bacteria and archaeal Methanosarcina species are nitrogen-containing tricyclic molecules with antibiotic, antitumoral, and antiparasitic activities. Phenazines are used as electron acceptors-donors in wide range of fields including environmental biosensors. In this study, the inhibitory effects of a synthetic phenazine dye, methylene violet 3RAX (also known as diethyl safranine) on human erythrocyte AChE and human plasma BChE were tested and also its inhibitory mechanisms for both enzymes were studied in detail. Kinetic analyses showed that methylene violet 3RAX acts as a hyperbolic noncompetitive inhibitor of AChE with K

Identifiants

DOI: 10.1016/j.cbi.2019.108845 PMID: 31593690
pubmed: 31593690
pii: S0009-2797(19)31135-4
doi: 10.1016/j.cbi.2019.108845
pii:
doi:

Substances chimiques

Cholinesterase Inhibitors 0
Phenothiazines 0
Acetylcholinesterase EC 3.1.1.7
Butyrylcholinesterase EC 3.1.1.8
methylene violet Y3G6PD8NRB

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

108845

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Seda Onder (S)

Department of Biochemistry, School of Pharmacy, Hacettepe University, Ankara, 06100, Turkey. Electronic address: sedaonder@hacettepe.edu.tr.

Kevser Biberoglu (K)

Department of Biochemistry, School of Pharmacy, Hacettepe University, Ankara, 06100, Turkey. Electronic address: kevserb@hacettepe.edu.tr.

Ozden Tacal (O)

Department of Biochemistry, School of Pharmacy, Hacettepe University, Ankara, 06100, Turkey. Electronic address: tacal@hacettepe.edu.tr.

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Acetylcholinesterase › The kinetics of inhibition of human...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Butyrylcholine esterase › The kinetics of inhibition of human...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › The kinetics of inhibition of human...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The kinetics of inhibition of human...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › The kinetics of inhibition of human...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Phénothiazines › The kinetics of inhibition of human...