PGC1α Suppresses Prostate Cancer Cell Invasion through ERRα Transcriptional Control.
Cell Line, Tumor
Cell Movement
/ genetics
Cell Proliferation
/ genetics
Datasets as Topic
Gene Expression Regulation, Neoplastic
Humans
Male
Neoplasm Invasiveness
/ genetics
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
/ metabolism
Promoter Regions, Genetic
/ genetics
Prostatic Neoplasms
/ genetics
Proto-Oncogene Proteins c-myc
/ genetics
Receptors, Estrogen
/ metabolism
Signal Transduction
/ genetics
Transcription, Genetic
ERRalpha Estrogen-Related Receptor
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 12 2019
15 12 2019
Historique:
received:
17
04
2019
revised:
27
08
2019
accepted:
04
10
2019
pubmed:
9
10
2019
medline:
28
5
2020
entrez:
10
10
2019
Statut:
ppublish
Résumé
The PPARγ coactivator 1 alpha (PGC1α) is a prostate tumor suppressor that controls the balance between anabolism and catabolism. PGC1A downregulation in prostate cancer is causally associated with the development of metastasis. Here we show that the transcriptional complex formed by PGC1α and estrogen-related receptor 1 alpha (ERRα) controls the aggressive properties of prostate cancer cells. PGC1α expression significantly decreased migration and invasion of various prostate cancer cell lines. This phenotype was consistent with remarkable cytoskeletal remodeling and inhibition of integrin alpha 1 and beta 4 expression, both
Identifiants
pubmed: 31594836
pii: 0008-5472.CAN-19-1231
doi: 10.1158/0008-5472.CAN-19-1231
doi:
Substances chimiques
MYC protein, human
0
PPARGC1A protein, human
0
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
0
Proto-Oncogene Proteins c-myc
0
Receptors, Estrogen
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6153-6165Subventions
Organisme : Cancer Research UK
ID : 24478
Pays : United Kingdom
Informations de copyright
©2019 American Association for Cancer Research.