Psychiatric disorders and SLC6A4 gene variants: possible effects on alcohol dependence and alzheimer's disease.
Adolescent
Adult
Aged
Aged, 80 and over
Alcoholism
/ complications
Alzheimer Disease
/ complications
Case-Control Studies
Cohort Studies
Comorbidity
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Greece
/ epidemiology
Humans
Italy
/ epidemiology
Linkage Disequilibrium
Mental Disorders
/ epidemiology
Middle Aged
Polymorphism, Genetic
Serotonin Plasma Membrane Transport Proteins
/ genetics
Young Adult
Alcohol dependence disorder
Alzheimer’s disease
Bipolar disorder
Genetics
SLC6A4
Schizophrenia
Journal
Molecular biology reports
ISSN: 1573-4978
Titre abrégé: Mol Biol Rep
Pays: Netherlands
ID NLM: 0403234
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
15
07
2019
accepted:
01
10
2019
pubmed:
9
10
2019
medline:
4
6
2020
entrez:
10
10
2019
Statut:
ppublish
Résumé
Serotoninergic system is one of the most important neurotransmission systems investigated in the field of psychiatry. Extensive evidence reveals how alterations of this system, and especially of the SLC6A4 gene, may be associated with psychiatric disorders. In this study we aimed to evaluate the pleiotropic nature of SLC6A4 alterations and their association with the overall risk of brain diseases rather than disorder-specific. SLC6A4 variants, namely 5HTTLPR, STin2, rs2066713, rs25531, rs4251417, rs6354 and rs7224199 were investigated in 4 independent cohorts of subjects with specific psychiatric disorders, including Alcohol dependence disorder (ALC), Alzheimer disease (ALZ), Schizophrenia (SCZ) and Bipolar disorder (BPD). Other variables (biochemical parameters and Psychiatric scales scores) were also tested for association. SLC6A4 polymorphisms are not associated with the risk of developing major psychiatric disorders (SCZ and BPD); however some signals were detected in ALC (HTTLPR p
Identifiants
pubmed: 31595439
doi: 10.1007/s11033-019-05119-5
pii: 10.1007/s11033-019-05119-5
doi:
Substances chimiques
SLC6A4 protein, human
0
Serotonin Plasma Membrane Transport Proteins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
191-200Commentaires et corrections
Type : ErratumIn
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