Targeting Inflammation by Flavonoids: Novel Therapeutic Strategy for Metabolic Disorders.
Animals
Anti-Inflammatory Agents
/ chemistry
Biomarkers
Clinical Trials as Topic
Disease Susceptibility
Drug Evaluation, Preclinical
Flavonoids
/ chemistry
Humans
Inflammation
/ complications
Inflammation Mediators
/ metabolism
Metabolic Diseases
/ diagnosis
Oxidative Stress
/ drug effects
Signal Transduction
/ drug effects
Treatment Outcome
flavonoids
inflammation
inflammatory mediators
metabolic disorders
nuclear factor-κB
oxidative stress
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Oct 2019
08 Oct 2019
Historique:
received:
29
08
2019
revised:
28
09
2019
accepted:
30
09
2019
entrez:
11
10
2019
pubmed:
11
10
2019
medline:
18
2
2020
Statut:
epublish
Résumé
A balanced metabolic profile is essential for normal human physiological activities. Disproportions in nutrition give rise to imbalances in metabolism that are associated with aberrant immune function and an elevated risk for inflammatory-associated disorders. Inflammation is a complex process, and numerous mediators affect inflammation-mediated disorders. The available clinical modalities do not effectively address the underlying diseases but rather relieve the symptoms. Therefore, novel targeted agents have the potential to normalize the metabolic system and, thus, provide meaningful therapy to the underlying disorder. In this connection, polyphenols, the well-known and extensively studied phytochemical moieties, were evaluated for their effective role in the restoration of metabolism via various mechanistic signaling pathways. The various flavonoids that we observed in this comprehensive review interfere with the metabolic events that induce inflammation. The mechanisms via which the polyphenols, in particular flavonoids, act provide a promising treatment option for inflammatory disorders. However, detailed clinical studies of such molecules are required to decide their clinical fate.
Identifiants
pubmed: 31597283
pii: ijms20194957
doi: 10.3390/ijms20194957
pmc: PMC6801776
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Biomarkers
0
Flavonoids
0
Inflammation Mediators
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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