The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation.

Anti-Retroviral Agents / therapeutic use CD4-Positive T-Lymphocytes / metabolism Female HIV Infections / drug therapy HIV-1 / drug effects Humans Phylogeny Viral Load Virus Latency / drug effects Virus Replication / drug effects

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
09 10 2019
Historique:
received: 04 01 2019
accepted: 29 08 2019
entrez: 11 10 2019
pubmed: 11 10 2019
medline: 15 9 2020
Statut: ppublish

Résumé

Although antiretroviral therapy (ART) is highly effective at suppressing HIV-1 replication, the virus persists as a latent reservoir in resting CD4

Identifiants

DOI: 10.1126/scitranslmed.aaw5589 PMID: 31597754 PMC: PMC7233356
pubmed: 31597754
pii: 11/513/eaaw5589
doi: 10.1126/scitranslmed.aaw5589
pmc: PMC7233356
mid: NIHMS1060174
pii:
doi:

Substances chimiques

Anti-Retroviral Agents 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Wellcome Trust
ID : 203135/Z/16/Z
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : UM1 AI126619
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI115981
Pays : United States
Organisme : FIC NIH HHS
ID : D43 TW000231
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI051794
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI050410
Pays : United States

Informations de copyright

Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Auteurs

Melissa-Rose Abrahams (MR)

Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.
ORCID: 0000-0002-1907-4929

Sarah B Joseph (SB)

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
ORCID: 0000-0001-9603-574X

Nigel Garrett (N)

Centre for the AIDS Programme of Research in South Africa, University of KwaZulu- Natal, Durban 4013, South Africa.
ORCID: 0000-0002-4530-234X

Lynn Tyers (L)

Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.
ORCID: 0000-0002-0535-9165

Matthew Moeser (M)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
ORCID: 0000-0002-1368-5171

Nancie Archin (N)

UNC HIV Cure Center and Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Olivia D Council (OD)

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

David Matten (D)

Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.
ORCID: 0000-0003-1085-4344

Shuntai Zhou (S)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
ORCID: 0000-0002-8353-386X

Deelan Doolabh (D)

Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.

Colin Anthony (C)

Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.
ORCID: 0000-0002-0108-6251

Nilu Goonetilleke (N)

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
UNC HIV Cure Center and Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Salim Abdool Karim (SA)

Centre for the AIDS Programme of Research in South Africa, University of KwaZulu- Natal, Durban 4013, South Africa.
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.
ORCID: 0000-0002-4986-2133

David M Margolis (DM)

Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
UNC HIV Cure Center and Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
ORCID: 0000-0001-5714-0002

Sergei Kosakovsky Pond (SK)

Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA 19122, USA.

Carolyn Williamson (C)

Division of Medical Virology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa. risunc@med.unc.edu carolyn.williamson@uct.ac.za.
National Health Laboratory Services of South Africa, University of Cape Town, Cape Town 7925, South Africa.
ORCID: 0000-0003-0125-1226

Ronald Swanstrom (R)

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. risunc@med.unc.edu carolyn.williamson@uct.ac.za.
Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
ORCID: 0000-0001-7777-0773

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiviraux › Antirétroviraux › The replication-competent HIV-1 latent...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › The replication-competent HIV-1 latent...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Infections à VIH › The replication-competent HIV-1 latent...
questionsmedicales.fr › Virus › Virus à ARN › Retroviridae › Lentivirus › Lentivirus des primates › VIH (Virus de l'Immunodéficience Humaine) › VIH-1 (Virus de l'Immunodéficience Humaine de type 1) › The replication-competent HIV-1 latent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The replication-competent HIV-1 latent...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › The replication-competent HIV-1 latent...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Charge virale › The replication-competent HIV-1 latent...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Latence virale › The replication-competent HIV-1 latent...
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › The replication-competent HIV-1 latent...