Impact of intravenous phenylephrine bolus administration on the nociceptive level index (NOL).
NOL index
Phenylephrine
Vasopressor
Journal
Journal of clinical monitoring and computing
ISSN: 1573-2614
Titre abrégé: J Clin Monit Comput
Pays: Netherlands
ID NLM: 9806357
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
31
07
2019
accepted:
22
09
2019
pubmed:
11
10
2019
medline:
29
10
2021
entrez:
11
10
2019
Statut:
ppublish
Résumé
Recently, the nociceptive level index (NOL) was shown to more specifically and sensitively detect noxious stimuli during anesthesia, in comparison to previous methods that relied on such parameters as heart rate (HR) and mean blood pressure (MAP). An ongoing study (NCT#03410485) evaluates the intraoperative combination of both NOL and bispectral (BIS) indices to improve quality of recovery after colorectal surgery. Our ethical committee (REB approval #CER15083) initially agreed on an interim analysis of the data from the first 30 patients. More specifically, this present report analyzed all the intravenous phenylephrine (PE) boluses administered during anesthesia as part of our study protocol to see whether they had a significant impact on NOL values as well as other parameters: HR, MAP, BIS index. For this trial, remifentanil and phenylephrine were given in both groups based on a specific algorithm. All study parameters were recorded electronically. Our analysis for the present specific outcome evaluated NOL index for 30 s before the intravenous PE bolus (1 µg kg
Identifiants
pubmed: 31598823
doi: 10.1007/s10877-019-00393-x
pii: 10.1007/s10877-019-00393-x
doi:
Substances chimiques
Phenylephrine
1WS297W6MV
Remifentanil
P10582JYYK
Types de publication
Clinical Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1079-1086Subventions
Organisme : Canadian Anesthesia Research Foundation
ID : CAS Research Award in Neuroanesthesia in memory of Adrienne Cheng
Organisme : Medasense Biometrics Ltd
ID : Investigator Initiated Trial Grant
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