Improved Survival of Children, Adolescents, and Young Adults With Head and Neck Soft Tissue Sarcomas in Denmark.
Journal
Journal of pediatric hematology/oncology
ISSN: 1536-3678
Titre abrégé: J Pediatr Hematol Oncol
Pays: United States
ID NLM: 9505928
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
pubmed:
11
10
2019
medline:
18
8
2020
entrez:
11
10
2019
Statut:
ppublish
Résumé
The aim of this study was to estimate nationally the survival of children, adolescents, and young adults with head and neck soft tissue sarcomas. The authors included patients 0 to 21 years of age and diagnosed with rhabdomyosarcoma (RMS) or nonrhabdomyosarcoma soft tissue sarcoma (NRSTS) located in the head and neck between 1980 and 2014. Survival probabilities were estimated using the Kaplan-Meier method. The authors estimated the effect of covariates with univariate and multivariate Cox regression analyses. The cumulative recurrence in RMS was estimated when considering death as a competing risk. We identified 72 patients (50% male individuals, whereas 72% had RMS). Elder patients (older than 15 y) did worse compared with younger patients (log-rank test P=0.001). Patients diagnosed from 1980 to 1999 did worse than patients diagnosed from 2000 to 2014 (log-rank test P=0.02). Similarly, younger (younger than 15 y) patients did significantly better when diagnosed from 2000 to 2014 with reference to those diagnosed from 1980 to 1999 (log-rank test P=0.026). The multivariate hazard ratio was 0.46 (95% confidence interval, 0.23-0.92) for patients diagnosed from 2000 to 2014 with reference to patients diagnosed from 1980 to 1999. The 1-year cumulative recurrence for RMS was 21.2% (95% confidence interval, 12.3%-35.0%). Overall survival has improved throughout the study period, which is attributable to advancement in diagnostics, treatment, and the application of standardized guidelines from international protocols.
Identifiants
pubmed: 31599853
doi: 10.1097/MPH.0000000000001615
pii: 00043426-202004000-00003
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
175-180Références
Radzikowska J, Kukwa W, Kukwa A, et al. Rhabdomyosarcoma of the head and neck in children. Contemp Oncol (Poznan, Poland). 2015;19:98–107.
Federico SM, Gilpin D, Samant S, et al. Clinical features and outcomes of young patients with head and neck non-rhabdomyosarcoma soft tissue sarcomas. Head Neck. 2015;37:76–83.
Jenney M. EpSSG RMS 2005: a protocol for non-metastatic rhabdomyosarcoma. 2005:1–203.
Oberlin O, Rey A, Sanchez de Toledo J, et al. Randomized comparison of intensified six-drug versus standard three-drug chemotherapy for high-risk nonmetastatic rhabdomyosarcoma and other chemotherapy-sensitive childhood soft tissue sarcomas: long-term results from the International Society of Pediatr. J Clin Oncol. 2012;30:2457–2465.
Stevens MCG, Rey A, Bouvet N, et al. Treatment of nonmetastatic rhabdomyosarcoma in childhood and adolescence: third study of the International Society of Paediatric Oncology—SIOP Malignant Mesenchymal Tumor 89. J Clin Oncol. 2005;23:2618–2628.
Daniel O, Veronique M, Soledad G, et al. Nonparameningeal head and neck rhabdomyosarcoma in children and adolescents: lessons from the consecutive International Society of Pediatric Oncology Malignant Mesenchymal Tumor studies. Head Neck. 2016;39:24–31.
Crist WM, Anderson JR, Meza JL, et al. Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease. J Clin Oncol. 2001;19:3091–3102.
Storm HH, Michelsen EV, Clemmensen IH, et al. The Danish Cancer Registry—history, content, quality and use. Dan Med Bull. 1997;44:535–539.
Pedersen CB. The Danish Civil Registration System. Scand J Public Health. 2011;39:22–25.
Bjerregaard B, Larsen OB. The Danish Pathology Register. Scand J Public Health. 2011;39:72–74.
Meira-Machado L, de Uña-Alvarez J, Cadarso-Suárez C, et al. Multi-state models for the analysis of time-to-event data. Stat Methods Med Res. 2009;18:195–222.
RStudio Team. RStudio: Integrated Development Environment for R 2016.
Therneau TM. A Package for Survival Analysis in S 2015.
Jr FEH. rms: Regression Modeling Strategies 2019.
Allignol A, Schumacher M, Beyersmann J. Empirical transition matrix of multi-state models: the etm package. J Stat Software. 2011:38.
Bob Gray. cmprsk: Subdistribution Analysis of Competing Risks. R package version 2.2-7. 2019.
Wickham H. ggplot2: Elegant Graphics for Data Analysis. New York, NY: Springer-Verlag; 2016.
EpSSG. Non-rhabdomyosarcoma L. EpSSG NRSTS 2005—Localized Non-Rhabdomyosarcoma Soft Tissue Sarcomas; 2009.
Peng KA, Grogan T, Wang MB. Head and neck sarcomas: analysis of the SEER database. Otolaryngol Head Neck Surg. 2014;151:627–633.
Sangkhathat S. Current management of pediatric soft tissue sarcomas. World J Clin Pediatr. 2015;4:94–105.
Waxweiler TV, Rusthoven CG, Proper MS, et al. Non-rhabdomyosarcoma soft tissue sarcomas in children: a surveillance, epidemiology, and end results analysis validating COG risk stratifications. Int J Radiat Oncol Biol Phys. 2015;92:339–348.