The structure of the serotonin system: A PET imaging study.
Clustering
MRI
PET
Serotonin
Structure
mRNA
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
15 01 2020
15 01 2020
Historique:
received:
25
04
2019
revised:
26
09
2019
accepted:
01
10
2019
pubmed:
11
10
2019
medline:
19
12
2020
entrez:
11
10
2019
Statut:
ppublish
Résumé
The human brain atlas of the serotonin (5-HT) system does not conform with commonly used parcellations of neocortex, since the spatial distribution of homogeneous 5-HT receptors and transporter is not aligned with such brain regions. This discrepancy indicates that a neocortical parcellation specific to the 5-HT system is needed. We first outline issues with an existing parcellation of the 5-HT system, and present an alternative parcellation derived from brain MR- and high-resolution PET images of five different 5-HT targets from 210 healthy controls. We then explore how well this new 5-HT parcellation can explain mRNA levels of all 5-HT genes. The parcellation derived here represents a characterization of the 5-HT system which is more stable and explains the underlying 5-HT molecular imaging data better than other atlases, and may hence be more sensitive to capture region-specific changes modulated by 5-HT.
Identifiants
pubmed: 31600591
pii: S1053-8119(19)30831-6
doi: 10.1016/j.neuroimage.2019.116240
pmc: PMC6951807
mid: NIHMS1544409
pii:
doi:
Substances chimiques
RNA, Messenger
0
Receptors, Serotonin
0
Serotonin
333DO1RDJY
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
116240Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB023281
Pays : United States
Organisme : NIBIB NIH HHS
ID : R21 EB018964
Pays : United States
Organisme : CIHR
ID : MOP 201403
Pays : Canada
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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