Maternal Gestational Diabetes Mellitus and Newborn DNA Methylation: Findings From the Pregnancy and Childhood Epigenetics Consortium.
Adult
Autism Spectrum Disorder
/ epidemiology
Case-Control Studies
Child
Cohort Studies
DNA Methylation
Diabetes Mellitus, Type 2
/ epidemiology
Diabetes, Gestational
/ epidemiology
Epigenesis, Genetic
/ physiology
Epigenome
/ physiology
Female
Fetal Blood
/ metabolism
Genome-Wide Association Study
Humans
Infant, Newborn
Male
Pregnancy
Prenatal Exposure Delayed Effects
/ genetics
Young Adult
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
14
03
2019
accepted:
17
09
2019
pubmed:
12
10
2019
medline:
15
9
2020
entrez:
12
10
2019
Statut:
ppublish
Résumé
Maternal gestational diabetes mellitus (GDM) has been associated with adverse outcomes in the offspring. Growing evidence suggests that the epigenome may play a role, but most previous studies have been small and adjusted for few covariates. The current study meta-analyzed the association between maternal GDM and cord blood DNA methylation in the Pregnancy and Childhood Epigenetics (PACE) consortium. Seven pregnancy cohorts (3,677 mother-newborn pairs [317 with GDM]) contributed results from epigenome-wide association studies, using DNA methylation data acquired by the Infinium HumanMethylation450 BeadChip array. Associations between GDM and DNA methylation were examined using robust linear regression, with adjustment for potential confounders. Fixed-effects meta-analyses were performed using METAL. Differentially methylated regions (DMRs) were identified by taking the intersection of results obtained using two regional approaches: comb-p and DMRcate. Two DMRs were identified by both comb-p and DMRcate. Both regions were hypomethylated in newborns exposed to GDM in utero compared with control subjects. One DMR (chr 1: 248100345-248100614) was located in the Maternal GDM was associated with lower cord blood methylation levels within two regions, including the promoter of
Identifiants
pubmed: 31601636
pii: dc19-0524
doi: 10.2337/dc19-0524
pmc: PMC6925578
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
98-105Subventions
Organisme : NIEHS NIH HHS
ID : K99 ES030400
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD034568
Pays : United States
Organisme : Wellcome Trust
ID : WT088806
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 084762MA
Pays : United Kingdom
Organisme : Wellcome Trust
ID : MC_UU_12013_8
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/6
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : T32 ES013678
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL111108
Pays : United States
Organisme : Medical Research Council
ID : G9815508
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : R00 ES025817
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES022934
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES007048
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK040561
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK048520
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_12013/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_19009
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12013/1-9
Pays : United Kingdom
Organisme : NIEHS NIH HHS
ID : P50 ES026086
Pays : United States
Organisme : NIEHS NIH HHS
ID : K99 ES025817
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA023108
Pays : United States
Organisme : Medical Research Council
ID : MC_PC_15018
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK103246
Pays : United States
Organisme : NINR NIH HHS
ID : R01 NR013945
Pays : United States
Informations de copyright
© 2019 by the American Diabetes Association.
Références
Ann Intern Med. 2014 Mar 18;160(6):414-20
pubmed: 24424622
Am J Obstet Gynecol. 1982 Dec 1;144(7):768-73
pubmed: 7148898
Int J Epidemiol. 2018 Feb 1;47(1):22-23u
pubmed: 29025028
Clin Epigenetics. 2017 Aug 15;9:86
pubmed: 28814982
Diabetes Care. 2010 Mar;33(3):676-82
pubmed: 20190296
Bioinformatics. 2012 Nov 15;28(22):2986-8
pubmed: 22954632
J Clin Endocrinol Metab. 2009 Jul;94(7):2464-70
pubmed: 19417040
Front Genet. 2018 Jun 22;9:222
pubmed: 29988451
Diabetes Care. 2012 Mar;35(3):526-8
pubmed: 22355019
BMC Med Genet. 2014 Oct 01;15:108
pubmed: 25269528
Am J Obstet Gynecol. 2005 Sep;193(3 Pt 2):1089-93
pubmed: 16157117
Diabetes Res Clin Pract. 2017 Oct;132:127-136
pubmed: 28834773
Epigenetics. 2013 Sep;8(9):935-43
pubmed: 23975224
Epigenetics. 2013 Feb;8(2):203-9
pubmed: 23314698
Diabet Med. 2018 May;35(5):612-620
pubmed: 29461653
Nat Commun. 2017 Oct 24;8(1):1011
pubmed: 29066808
Neurosci Biobehav Rev. 2018 Nov;94:17-30
pubmed: 30067938
Diabetes. 2013 Apr;62(4):1320-8
pubmed: 23209187
Obstet Gynecol Clin North Am. 2017 Jun;44(2):207-217
pubmed: 28499531
Medicine (Baltimore). 2018 Jan;97(2):e9438
pubmed: 29480832
FASEB J. 2014 Nov;28(11):4868-79
pubmed: 25145626
Hum Mol Genet. 2015 Jun 1;24(11):3021-9
pubmed: 25634562
Clin Epigenetics. 2017 Mar 27;9:28
pubmed: 28360945
Diabetologia. 2014 Jan;57(1):102-9
pubmed: 24065154
Acta Obstet Gynecol Scand. 2017 May;96(5):563-569
pubmed: 28027410
Br J Clin Pharmacol. 2003 Jan;55(1):77-85
pubmed: 12534643
Bioinformatics. 2010 Sep 1;26(17):2190-1
pubmed: 20616382
BMC Med. 2018 Nov 6;16(1):203
pubmed: 30396349
Prev Chronic Dis. 2014 Jun 19;11:E104
pubmed: 24945238
Exp Diabetes Res. 2012;2012:963735
pubmed: 22927834
Genome Biol. 2014 Feb 04;15(2):R31
pubmed: 24495553
Diabetes Res Clin Pract. 2018 Aug;142:10-18
pubmed: 29596946
Epigenomics. 2015 Oct;7(7):1111-22
pubmed: 26586120
Diabetes. 2013 Apr;62(4):1026-8
pubmed: 23520280
Hum Mol Genet. 2017 Oct 15;26(20):4067-4085
pubmed: 29016858