Simulated microgravity-mediated reversion of murine lymphoma immune evasion.
Animals
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Cell Culture Techniques
/ methods
Cell Line, Tumor
Cell Proliferation
Coculture Techniques
Cosmic Radiation
/ adverse effects
Humans
Lymphoma
/ immunology
Mice
Space Flight
Tumor Escape
/ immunology
Weightlessness Simulation
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 10 2019
10 10 2019
Historique:
received:
27
08
2019
accepted:
25
09
2019
entrez:
12
10
2019
pubmed:
12
10
2019
medline:
11
11
2020
Statut:
epublish
Résumé
No human has returned to the moon since the end of the Apollo program 47 years ago, however, new missions are planned for an orbital outpost. Space radiation and the potential for cancer remain as important issues to the future of human space exploration. While improved shield technologies and protective biologicals are under development, little is known concerning the interaction between cancer cells and host immunity in microgravity. As a hallmark of cancer, tumor cells employ mechanisms of immune evasion to avoid elimination by protective CD4
Identifiants
pubmed: 31602007
doi: 10.1038/s41598-019-51106-y
pii: 10.1038/s41598-019-51106-y
pmc: PMC6787044
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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