Co-Infection of Scrub Typhus and Human Granulocytic Anaplasmosis in Korea, 2006.
Adolescent
Adult
Aged
Aged, 80 and over
Anaplasma phagocytophilum
/ classification
Anaplasmosis
/ diagnosis
Coinfection
/ diagnosis
Female
Humans
Male
Middle Aged
Phlebovirus
/ genetics
Phylogeny
Polymerase Chain Reaction
RNA, Ribosomal, 16S
/ genetics
RNA, Viral
/ genetics
Republic of Korea
Retrospective Studies
Scrub Typhus
/ diagnosis
Young Adult
Anaplasma phagocytophilum
Co-Infection
Human Granulocytic Anaplasmosis
Scrub Typhus
Severe Fever with Thrombocytopenia Syndrome
Journal
Journal of Korean medical science
ISSN: 1598-6357
Titre abrégé: J Korean Med Sci
Pays: Korea (South)
ID NLM: 8703518
Informations de publication
Date de publication:
14 Oct 2019
14 Oct 2019
Historique:
received:
16
07
2019
accepted:
22
08
2019
entrez:
12
10
2019
pubmed:
12
10
2019
medline:
26
2
2020
Statut:
epublish
Résumé
Scrub typhus, severe fever with thrombocytopenia syndrome (SFTS) and human granulocytic anaplasmosis (HGA) are important arthropod-borne infectious diseases in Korea and share a common point that they are transmitted by arthropod bites mostly during outdoor activities and there are considerable overlaps of epidemiologic and clinical features at presentation. We investigated the co-infection of these infections. The study subjects were patients with laboratory-confirmed scrub typhus who were enrolled retrospectively in 2006. SFTS virus (SFTSV) infection was confirmed by a reverse transcriptase polymerase chain reaction (PCR) to amplify partial L segment of SFTSV for molecular diagnosis. HGA was confirmed by a nested PCR to amplify 16S rRNA gene of One-hundred sixty-seven patients with scrub typhus were included in the analysis. Co-infection of We found retrospective molecular evidence of the co-infection of scrub typhus and HGA in Korea. HGA may be more prevalent than expected and need to be considered as an important differential diagnosis of febrile patients in Korea.
Sections du résumé
BACKGROUND
BACKGROUND
Scrub typhus, severe fever with thrombocytopenia syndrome (SFTS) and human granulocytic anaplasmosis (HGA) are important arthropod-borne infectious diseases in Korea and share a common point that they are transmitted by arthropod bites mostly during outdoor activities and there are considerable overlaps of epidemiologic and clinical features at presentation. We investigated the co-infection of these infections.
METHODS
METHODS
The study subjects were patients with laboratory-confirmed scrub typhus who were enrolled retrospectively in 2006. SFTS virus (SFTSV) infection was confirmed by a reverse transcriptase polymerase chain reaction (PCR) to amplify partial L segment of SFTSV for molecular diagnosis. HGA was confirmed by a nested PCR to amplify 16S rRNA gene of
RESULTS
RESULTS
One-hundred sixty-seven patients with scrub typhus were included in the analysis. Co-infection of
CONCLUSION
CONCLUSIONS
We found retrospective molecular evidence of the co-infection of scrub typhus and HGA in Korea. HGA may be more prevalent than expected and need to be considered as an important differential diagnosis of febrile patients in Korea.
Identifiants
pubmed: 31602827
pii: 34.e257
doi: 10.3346/jkms.2019.34.e257
pmc: PMC6786965
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
RNA, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e257Subventions
Organisme : Seoul Metropolitan Government Seoul National University (SMG-SNU) Boramae Medical Center
Pays : Korea
Informations de copyright
© 2019 The Korean Academy of Medical Sciences.
Déclaration de conflit d'intérêts
The authors have no potential conflicts of interest to disclose.
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