Biophysical and in Vivo Studies Identify a New Natural-Based Polyphenol, Counteracting Aβ Oligomerization in Vitro and Aβ Oligomer-Mediated Memory Impairment and Neuroinflammation in an Acute Mouse Model of Alzheimer's Disease.
Acute Disease
Alzheimer Disease
/ chemically induced
Amyloid beta-Peptides
/ chemistry
Animals
Cells, Cultured
Disease Models, Animal
Inflammation
/ chemically induced
Memory Disorders
/ chemically induced
Mice
Mice, Inbred C57BL
Molecular Docking Simulation
/ methods
Peptide Fragments
/ chemistry
Polyphenols
/ chemistry
Protein Structure, Secondary
NMR
animal model
docking
inflammation
memory
polyphenols
β-Amyloid
Journal
ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337
Informations de publication
Date de publication:
20 11 2019
20 11 2019
Historique:
pubmed:
12
10
2019
medline:
26
9
2020
entrez:
12
10
2019
Statut:
ppublish
Résumé
In this study natural-based complex polyphenols, obtained through a smart synthetic approach, have been evaluated for their ability to inhibit the formation of Aβ
Identifiants
pubmed: 31603646
doi: 10.1021/acschemneuro.9b00241
doi:
Substances chimiques
Amyloid beta-Peptides
0
Peptide Fragments
0
Polyphenols
0
amyloid beta-protein (1-42)
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM