Investigating the neural basis of cognitive control dysfunction in mood disorders.
Adult
Attention
/ physiology
Bipolar Disorder
/ physiopathology
Cognition
/ physiology
Cognitive Dysfunction
/ physiopathology
Depressive Disorder, Major
/ physiopathology
Executive Function
/ physiology
Female
Humans
Magnetic Resonance Imaging
Male
Memory, Short-Term
/ physiology
Prefrontal Cortex
/ physiopathology
Young Adult
bipolar disorders
cognitive control
depression
euthymic
fMRI activation
Journal
Bipolar disorders
ISSN: 1399-5618
Titre abrégé: Bipolar Disord
Pays: Denmark
ID NLM: 100883596
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
pubmed:
12
10
2019
medline:
15
12
2020
entrez:
12
10
2019
Statut:
ppublish
Résumé
Dysfunction of cognitive control is a feature of both bipolar disorder (BP) and major depression (MDD) and persists through to remission. However, it is unknown whether these disorders are characterized by common or distinct disruptions of cognitive control function and its neural basis. We investigated this gap in knowledge in asymptomatic BP and MDD participants, interpreted within a framework of normative function. Participants underwent fMRI scans engaging cognitive control through a working memory task and completed a cognitive battery evaluating performance across multiple subdomains of cognitive control, including attention, impulsivity, processing speed, executive function, and memory. Analysis was performed in two stages: (i) cognitive control-related brain activation and deactivation were correlated with cognitive control performance in 115 healthy controls (HCs), then, (ii) significantly correlated regions from (i) were compared between 25 asymptomatic BP, 25 remitted MDD, and with 25 different HCs, matched for age and gender. Impulsivity and executive function performance were significantly worse in BP compared to both MDD and HCs. Both BP and MDD had significantly poorer memory performance compared to HCs. Greater deactivation of the medial prefrontal cortex (MPFC) during the fMRI task was associated with better executive function in healthy controls. Significantly less deactivation in this region was present in both BP and MDD compared to HCs. Failure to deactivate the MPFC, a key region of the default mode network, during working memory processing is a shared neural feature present in both bipolar and major depression and could be a source of common cognitive dysfunction.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
286-295Subventions
Organisme : Parker Hughes Bequest
Pays : International
Organisme : Heart Research Institute
Pays : International
Organisme : National Health and Medical Research Council
ID : APP1073041
Pays : International
Organisme : National Health and Medical Research Council
ID : APP1087560
Pays : International
Organisme : National Health and Medical Research Council
ID : APP1090148
Pays : International
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Références
Porter RJ, Robinson LJ, Malhi GS, Gallagher P. The neurocognitive profile of mood disorders - a review of the evidence and methodological issues. Bipolar Disord. 2015;17:21-40.
Cotrena C, Branco LD, Shansis FM, Fonseca RP. Executive function impairments in depression and bipolar disorder: association with functional impairment and quality of life. J Affect Disord. 2016;190:744-753.
Fritz K, Russell A, Allwang C, Kuiper S, Lampe L, Malhi GS. Is a delay in the diagnosis of bipolar disorder inevitable? Bipolar Disord. 2017;19:396-400.
Perlis RH, Ostacher MJ, Goldberg JF, et al. Transition to mania during treatment of bipolar depression. Neuropsychopharmacology. 2010;35:2545-2552.
Han KM, De Berardis D, Fornaro M, Kim YK. Differentiating between bipolar and unipolar depression in functional and structural MRI studies. Prog Neuropsychopharmacol Biol Psychiatry. 2018;91:20-27.
Cardoso de Almeida JR, Phillips ML. Distinguishing between unipolar depression and bipolar depression: current and future clinical and neuroimaging perspectives. Biol Psychiatry. 2013;73:111-118.
MacQueen GM, Memedovich KA. Cognitive dysfunction in major depression and bipolar disorder: Assessment and treatment options. Psychiatry Clin Neurosci. 2017;71:18-27.
Rock PL, Roiser JP, Riedel WJ, Blackwell AD. Cognitive impairment in depression: a systematic review and meta-analysis. Psychol Med. 2014;44:2029-2040.
Malhi GS, Ivanovski B, Hadzi-Pavlovic D, Mitchell PB, Vieta E, Sachdev P. Neuropsychological deficits and functional impairment in bipolar depression, hypomania and euthymia. Bipolar Disord. 2007;9:114-125.
Depp CA, Dev S, Eyler LT. Bipolar Depression and Cognitive Impairment: Shared Mechanisms and New Treatment Avenues. Psychiatr Clin North Am. 2016;39:95-109.
Daniel BD, Montali A, Gerra ML, et al. Cognitive impairment and its associations with the path of illness in affective disorders: a comparison between patients with bipolar and unipolar depression in remission. Journal of psychiatric practice. 2013;19:275-287.
Lee CY, Wang LJ, Lee Y, et al. Differentiating bipolar disorders from unipolar depression by applying the Brief Assessment of Cognition in Affective Disorders. Psychol Med. 2018;48:929-938.
Stoddart S, Craddock NJ, Jones LA. Differentiation of executive and attention impairments in affective illness. Psychol Med. 2007;37:1613-1623.
Smith YR, Love T, Persad CC, Tkaczyk A, Nichols TE, Zubieta J-K. Impact of combined estradiol and norethindrone therapy on visuospatial working memory assessed by functional magnetic resonance imaging. J Clin Endocrinol Metab. 2006;91:4476-4481.
Niendam TA, Laird AR, Ray KL, Dean YM, Glahn DC, Carter CS. Meta-analytic evidence for a superordinate cognitive control network subserving diverse executive functions. Cogn Affect Behav Neurosci. 2012;12:241-268.
Anticevic A, Cole MW, Murray JD, Corlett PR, Wang XJ, Krystal JH. The role of default network deactivation in cognition and disease. Trends Cogn Sci. 2012;16:584-592.
Dosenbach NU, Fair DA, Miezin FM, et al. Distinct brain networks for adaptive and stable task control in humans. Proc Natl Acad Sci U S A. 2007;104:11073-11078.
Daselaar SM, Prince SE, Cabeza R. When less means more: deactivations during encoding that predict subsequent memory. NeuroImage. 2004;23:921-927.
Rayner G, Jackson G, Wilson S. Cognition-related brain networks underpin the symptoms of unipolar depression: Evidence from a systematic review. Neurosci Biobehav Rev. 2016;61:53-65.
Ongur D, Lundy M, Greenhouse I, et al. Default mode network abnormalities in bipolar disorder and schizophrenia. Psychiatry Res. 2010;183:59-68.
Rodríguez-Cano E, Alonso-Lana S, Sarró S, et al. Differential failure to deactivate the default mode network in unipolar and bipolar depression. Bipolar Disord. 2017;19:386-395.
Cerullo MA, Eliassen JC, Smith CT, et al. Bipolar I disorder and major depressive disorder show similar brain activation during depression. Bipolar Disord. 2014;16:703-712.
Ryan KA, Dawson EL, Kassel MT, et al. Shared dimensions of performance and activation dysfunction in cognitive control in females with mood disorders. Brain. 2015;138:1424-1434.
Bertocci MA, Bebko GM, Mullin BC, et al. Abnormal anterior cingulate cortical activity during emotional n-back task performance distinguishes bipolar from unipolar depressed females. Psychol Med. 2012;42:1417-1428.
Rive MM, Mocking RT, Koeter MJ, et al. State-dependent differences in emotion regulation between unmedicated bipolar disorder and major depressive disorder. JAMA Psychiatry. 2015;72:687-696.
Rive MM, Redlich R, Schmaal L, et al. Distinguishing medication-free subjects with unipolar disorder from subjects with bipolar disorder: state matters. Bipolar Disord. 2016;18:612-623.
Sheline YI, Barch DM, Price JL, et al. The default mode network and self-referential processes in depression. Proc Natl Acad Sci USA. 2009;106:1942-1947.
Pomarol-Clotet E, Alonso-Lana S, Moro N, et al. Brain functional changes across the different phases of bipolar disorder. Br J Psychiatry. 2015;206:136-144.
Sheehan DV, Lecrubier Y, Sheehan KH, et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry. 1998;59(Suppl 20):pp. 22-33;quiz 34-57.
Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56-62.
Young RC, Biggs JT, Ziegler VE, Meyer DA. A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry. 1978;133:429-435.
Lovibond PF, Lovibond SH. The structure of negative emotional states: comparison of the Depression Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. Behav Res Ther. 1995;33:335-343.
Breukelaar IA, Antees C, Grieve SM, et al. Cognitive control network anatomy correlates with neurocognitive behavior: A longitudinal study. Hum Brain Mapp. 2017;38:631-643.
Silverstein SM, Berten S, Olson P, et al. Development and validation of a World-Wide-Web-based neurocognitive assessment battery: WebNeuro. Behav Res Methods. 2007;39:940-949.
Breukelaar IA, Williams LM, Antees C, et al. Cognitive ability is associated with changes in the functional organization of the cognitive control brain network. Hum Brain Mapp. 2018;39:5028-5038.
Korgaonkar MS, Grieve SM, Etkin A, Koslow SH, Williams LM. Using standardized fMRI protocols to identify patterns of prefrontal circuit dysregulation that are common and specific to cognitive and emotional tasks in major depressive disorder: first wave results from the iSPOT-D study. Neuropsychopharmacology. 2013;38:863-871.
Bartova L, Meyer BM, Diers K, et al. Reduced default mode network suppression during a working memory task in remitted major depression. J Psychiatr Res. 2015;64:9-18.
Kerestes R, Ladouceur CD, Meda S, et al. Abnormal prefrontal activity subserving attentional control of emotion in remitted depressed patients during a working memory task with emotional distracters. Psychol Med. 2012;42:29-40.
Walter H, Wolf RC, Spitzer M, Vasic N. Increased left prefrontal activation in patients with unipolar depression: an event-related, parametric, performance-controlled fMRI study. J Affect Disord. 2007;101:175-185.
Harvey PO, Fossati P, Pochon JB, et al. Cognitive control and brain resources in major depression: an fMRI study using the n-back task. NeuroImage. 2005;26:860-869.
Narayanan NS, Prabhakaran V, Bunge SA, Christoff K, Fine EM, Gabrieli JD. The role of the prefrontal cortex in the maintenance of verbal working memory: an event-related FMRI analysis. Neuropsychology. 2005;19:223-232.
Wessa M, Houenou J, Paillère-Martinot M-L, et al. Fronto-Striatal Overactivation in Euthymic Bipolar Patients During an Emotional Go/NoGo Task. Am J Psychiatry. 2007;164:638-646.
Korgaonkar MS, Erlinger M, Breukelaar IA, et al. Amygdala Activation and Connectivity to Emotional Processing Distinguishes Asymptomatic Patients With Bipolar Disorders and Unipolar Depression. Biol Psychiatry Cogn Neurosci Neuroimaging. 2018;4:361-370.
Malhi GS, Byrow Y, Fritz K, et al. Mood disorders: neurocognitive models. Bipolar Disord. 2015;17:3-20.
Buhle JT, Silvers JA, Wager TD, et al. Cognitive reappraisal of emotion: a meta-analysis of human neuroimaging studies. Cereb Cortex. 2014;24:2981-2990.
Salgado-Pineda P, Radua J, Sarró S, et al. Sensitivity and specificity of hypoactivations and failure of de-activation in schizophrenia. Schizophr Res. 2018;201:224-230.
Etkin A, Patenaude B, Song YJ, et al. A cognitive-emotional biomarker for predicting remission with antidepressant medications: a report from the iSPOT-D trial. Neuropsychopharmacology. 2015;40:1332-1342.
Sole B, Jimenez E, Torrent C, et al. Cognitive Impairment in Bipolar Disorder: Treatment and Prevention Strategies. Int J Neuropsychopharmacol. 2017;20:670-680.
Martinez-Aran A, Vieta E, Torrent C, et al. Functional outcome in bipolar disorder: the role of clinical and cognitive factors. Bipolar Disord. 2007;9:103-113.
Hafeman DM, Chang KD, Garrett AS, Sanders EM, Phillips ML. Effects of medication on neuroimaging findings in bipolar disorder: an updated review. Bipolar Disord. 2012;14:375-410.
Laidi C, Houenou J. Brain functional effects of psychopharmacological treatments in bipolar disorder. Eur Neuropsychopharmacol. 2016;26:1695-1740.