Food-induced stimulation of the antisecretory factor to improve symptoms in Meniere's disease: our results.
Adult
Aged
Dexamethasone
/ administration & dosage
Edible Grain
/ metabolism
Female
Glycerol
/ administration & dosage
Humans
Male
Meniere Disease
/ diagnosis
Middle Aged
Neuropeptides
/ metabolism
Peripheral Nervous System Agents
/ administration & dosage
Quality of Life
Surveys and Questionnaires
Tinnitus
/ diagnosis
Vertigo
/ drug therapy
Endogenous antisecretory factor
Hearing loss
Meniere’s disease
Specially processed cereals
Vertigo
Journal
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
ISSN: 1434-4726
Titre abrégé: Eur Arch Otorhinolaryngol
Pays: Germany
ID NLM: 9002937
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
05
09
2019
accepted:
01
10
2019
pubmed:
13
10
2019
medline:
11
11
2020
entrez:
13
10
2019
Statut:
ppublish
Résumé
Specially processed cereals (SPC) that increase endogenous antisecretory factor (AF) synthesis have been proposed to improve symptoms of Meniere's disease (MD) with controversial results. The aim of this study was to evaluate the effects of SPC in patients with definite unilateral MD and compare the results to a treatment protocol with intravenous glycerol and dexamethasone. Thirteen patients with unilateral MD were treated with SPC and 13 patients were treated with intravenous glycerol and dexamethasone for 12 months. Audio-vestibular evaluation was performed before (T0) and at the end of the treatments (T12). The number of vertigo spells were evaluated before and after therapy and the Efficacy Index (EI) was calculated. Questionnaires for hearing loss (HHIA), tinnitus (THI) and quality of life (TFL) were administered. EI decreased in the SPC group in the second semester compared to the first although not significantly (p = 0.6323). There was a significant reduction for THI score in the SPC group at T12 (p = 0.0325). No significant differences were found between the two groups at T0 (p = 0.4723), while a significant difference was found at T12 (p = 0.0041). Quality of life showed an improvement in daily activities in the SPC group compared to infusion therapy group. Our study shows a reduced number of vertigo attacks and a positive effect on the discomfort generated by tinnitus and quality of life in patients with unilateral MD treated with SPC and when compared to patients treated with intravenous glycerol and dexamethasone. No effects on hearing thresholds were noted in both groups.
Identifiants
pubmed: 31605188
doi: 10.1007/s00405-019-05682-4
pii: 10.1007/s00405-019-05682-4
doi:
Substances chimiques
Neuropeptides
0
Peripheral Nervous System Agents
0
antisecretory factor
0
Dexamethasone
7S5I7G3JQL
Glycerol
PDC6A3C0OX
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
77-83Références
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