The five dimensions of B cell tolerance.
ABO incompatibility
B lymphocytes
accommodation
antibodies
tolerance
Journal
Immunological reviews
ISSN: 1600-065X
Titre abrégé: Immunol Rev
Pays: England
ID NLM: 7702118
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
pubmed:
15
10
2019
medline:
6
5
2020
entrez:
15
10
2019
Statut:
ppublish
Résumé
B cell tolerance has been generally understood to be an acquired property of the immune system that governs antibody specificity in ways that avoid auto-toxicity. As useful as this understanding has proved, it fails to fully explain the existence of auto-reactive specificities in healthy individuals and contribution these may have to health. Mechanisms underlying B cell tolerance are considered to select a clonal repertoire that generates a collection of antibodies that do not bind self, ie tolerance operates more or less in three dimensions that largely spare autologous cells and antigens. Yet, most B lymphocytes in humans and probably in other vertebrates are auto-reactive and absence of these auto-reactive B cells is associated with disease. We suggest that auto-reactivity can be embodied by extending the concept of tolerance by two further dimensions, one of time and circumstance and one that allows healthy cells to actively resist injury. In this novel concept, macromolecular recognition by the B cell receptor leading to deletion, anergy, receptor editing or B cell activation is extended by taking account of the time of development of normal immune responses (4th dimension) and the accommodation (or tolerance) of normal cells to bound antibody, activation of complement, and interaction with inflammatory cells (fifth dimension). We discuss how these dimensions contribute to understanding B cell biology in health or disease.
Identifiants
pubmed: 31609002
doi: 10.1111/imr.12813
pmc: PMC10387221
mid: NIHMS1918122
doi:
Substances chimiques
Antibodies
0
Autoantigens
0
Receptors, Antigen, B-Cell
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
180-193Subventions
Organisme : NIAID NIH HHS
ID : R21 AI159219
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI151588
Pays : United States
Organisme : NIH HHS
ID : R01AI122369
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB022033
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI122369
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI117561
Pays : United States
Organisme : NIH HHS
ID : EB022033
Pays : United States
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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