Metabolic stress is a primary pathogenic event in transgenic
Alzheimer Disease
/ genetics
Amyloid beta-Peptides
/ genetics
Animals
Animals, Genetically Modified
Caenorhabditis elegans
/ drug effects
Citric Acid Cycle
/ drug effects
Disease Models, Animal
Humans
Hypoglycemic Agents
/ pharmacology
Ketoglutarate Dehydrogenase Complex
/ genetics
Metabolic Flux Analysis
Metformin
/ pharmacology
Mitochondria
/ drug effects
Neurons
/ drug effects
Protein Aggregates
/ drug effects
Protein Carbonylation
Stress, Physiological
/ drug effects
C. elegans
TCA cycle
amyloid beta
metabolism
metformin
mitochondria
neuroscience
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
15 10 2019
15 10 2019
Historique:
received:
10
07
2019
accepted:
23
09
2019
entrez:
16
10
2019
pubmed:
16
10
2019
medline:
25
2
2020
Statut:
epublish
Résumé
Alzheimer's disease (AD) is the most common neurodegenerative disease affecting the elderly worldwide. Mitochondrial dysfunction has been proposed as a key event in the etiology of AD. We have previously modeled amyloid-beta (Aβ)-induced mitochondrial dysfunction in a transgenic
Identifiants
pubmed: 31610847
doi: 10.7554/eLife.50069
pii: 50069
pmc: PMC6794093
doi:
pii:
Substances chimiques
Amyloid beta-Peptides
0
Hypoglycemic Agents
0
Protein Aggregates
0
Metformin
9100L32L2N
Ketoglutarate Dehydrogenase Complex
EC 1.2.4.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education - Singapore
ID : NGS Scholarship
Pays : International
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Organisme : Swiss National Science Foundation
ID : 163390
Pays : Switzerland
Organisme : Yale-NUS
ID : IG17-LR006
Pays : International
Organisme : Ministry of Education - Singapore
ID : 2014-T2-2-120
Pays : International
Organisme : Ministry of Education - Singapore
ID : R-184-000-230-112
Pays : International
Informations de copyright
© 2019, Teo et al.
Déclaration de conflit d'intérêts
ET, SR, DB, HK, SF, AC, TT, JC, JK, MW, RG, PM, BH, NT, JG No competing interests declared
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