Somnolence Preceded the Development of a Subthalamic Lesion in Neuromyelitis Optica Spectrum Disorder.
Aged
Central Nervous System Stimulants
/ therapeutic use
Female
Humans
Japan
Magnetic Resonance Imaging
/ methods
Methylphenidate
/ therapeutic use
Modafinil
/ therapeutic use
Narcolepsy
/ drug therapy
Neuromyelitis Optica
/ complications
Sleepiness
Subthalamus
/ abnormalities
Treatment Outcome
Wakefulness-Promoting Agents
/ therapeutic use
hypothalamic lesion
methylphenidate
modafinil
neuromyelitis optica spectrum disorder
orexin
somnolence
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
15 Feb 2020
15 Feb 2020
Historique:
pubmed:
16
10
2019
medline:
1
9
2020
entrez:
16
10
2019
Statut:
ppublish
Résumé
A 67-year-old woman with neuromyelitis optica spectrum disorder (NMOSD) developed severe somnolence. Ten days after admission, fluid-attenuated inversion-recovery magnetic resonance imaging (MRI) revealed hyperintense areas around the bilateral hypothalamus, which were not present on MRI at admission. The orexin level, which is decreased in idiopathic narcolepsy, was slightly decreased in her cerebrospinal fluid. Immunosuppressive treatment and methylphenidate markedly improved her somnolence. This case shows that NMOSD in the acute phase can cause somnolence in a patient without apparent lesions in the hypothalamus.
Identifiants
pubmed: 31611526
doi: 10.2169/internalmedicine.2947-19
pmc: PMC7056378
doi:
Substances chimiques
Central Nervous System Stimulants
0
Wakefulness-Promoting Agents
0
Methylphenidate
207ZZ9QZ49
Modafinil
R3UK8X3U3D
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
577-579Références
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