Transportin-1 binds to the HIV-1 capsid via a nuclear localization signal and triggers uncoating.
Active Transport, Cell Nucleus
Binding Sites
CD4-Positive T-Lymphocytes
/ metabolism
Capsid
/ chemistry
Capsid Proteins
/ chemistry
Gene Deletion
HEK293 Cells
HIV Infections
/ genetics
HIV-1
/ metabolism
HeLa Cells
Humans
Mass Spectrometry
Models, Molecular
Nuclear Localization Signals
Protein Binding
Protein Conformation
RNA, Viral
/ metabolism
Virus Uncoating
beta Karyopherins
/ chemistry
Journal
Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
22
09
2018
accepted:
30
08
2019
pubmed:
16
10
2019
medline:
8
2
2020
entrez:
16
10
2019
Statut:
ppublish
Résumé
The initial steps of HIV replication in host cells prime the virus for passage through the nuclear pore and drive the establishment of a productive and irreparable infection
Identifiants
pubmed: 31611641
doi: 10.1038/s41564-019-0575-6
pii: 10.1038/s41564-019-0575-6
doi:
Substances chimiques
Capsid Proteins
0
Nuclear Localization Signals
0
RNA, Viral
0
TNPO1 protein, human
0
beta Karyopherins
0
Types de publication
Letter
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM