Common functional networks in the mouse brain revealed by multi-centre resting-state fMRI analysis.

Animals Brain / diagnostic imaging Connectome / methods Female Image Processing, Computer-Assisted / methods Magnetic Resonance Imaging / methods Male Mice Mice, Inbred C57BL Nerve Net / diagnostic imaging Reproducibility of Results
Connectome Default-mode network Functional connectivity ICA Seed-based

Journal

NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515

Informations de publication

Date de publication:
15 01 2020
Historique:
received: 06 05 2019
revised: 04 10 2019
accepted: 11 10 2019
pubmed: 16 10 2019
medline: 19 12 2020
entrez: 16 10 2019
Statut: ppublish

Résumé

Preclinical applications of resting-state functional magnetic resonance imaging (rsfMRI) offer the possibility to non-invasively probe whole-brain network dynamics and to investigate the determinants of altered network signatures observed in human studies. Mouse rsfMRI has been increasingly adopted by numerous laboratories worldwide. Here we describe a multi-centre comparison of 17 mouse rsfMRI datasets via a common image processing and analysis pipeline. Despite prominent cross-laboratory differences in equipment and imaging procedures, we report the reproducible identification of several large-scale resting-state networks (RSN), including a mouse default-mode network, in the majority of datasets. A combination of factors was associated with enhanced reproducibility in functional connectivity parameter estimation, including animal handling procedures and equipment performance. RSN spatial specificity was enhanced in datasets acquired at higher field strength, with cryoprobes, in ventilated animals, and under medetomidine-isoflurane combination sedation. Our work describes a set of representative RSNs in the mouse brain and highlights key experimental parameters that can critically guide the design and analysis of future rodent rsfMRI investigations.

Identifiants

DOI: 10.1016/j.neuroimage.2019.116278 PMID: 31614221 PMC: PMC7116112
pubmed: 31614221
pii: S1053-8119(19)30869-9
doi: 10.1016/j.neuroimage.2019.116278
pmc: PMC7116112
mid: EMS95145
pii:
doi:

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

116278

Subventions

Organisme : European Research Council
ID : 802371
Pays : International

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Références

Front Neuroanat. 2012 Jul 26;6:29
pubmed: 22855672
Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4734-9
pubmed: 20176931
PLoS One. 2011;6(10):e25701
pubmed: 22028788
Neural Plast. 2016;2016:6846721
pubmed: 27034849
Chaos. 2017 Apr;27(4):047405
pubmed: 28456172
Neuroimage. 2018 May 15;172:9-20
pubmed: 29414498
Neuroimage. 2015 Dec;123:11-21
pubmed: 26296501
J Neurosci. 2014 Oct 8;34(41):13780-9
pubmed: 25297104
Neuroimage. 2013 Jul 1;74:326-36
pubmed: 23454471
Science. 2015 Jun 12;348(6240):1241-4
pubmed: 26068849
J Cereb Blood Flow Metab. 1997 Mar;17(3):301-8
pubmed: 9119903
Neuroimage. 2016 Feb 15;127:496-509
pubmed: 26706448
Biol Psychiatry. 2017 May 1;81(9):778-788
pubmed: 28185645
Transl Psychiatry. 2015 Feb 17;5:e512
pubmed: 25689573
Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3979-84
pubmed: 22355129
Neuroimage. 2017 Apr 1;149:190-199
pubmed: 28159688
Eur Neuropsychopharmacol. 2016 Jul;26(7):1150-60
pubmed: 27061851
Alzheimers Dement. 2016 Sep;12(9):964-976
pubmed: 27107518
NMR Biomed. 2013 Jun;26(6):638-50
pubmed: 23303725
Nature. 2007 Jan 11;445(7124):168-76
pubmed: 17151600
PLoS One. 2011 Apr 18;6(4):e18876
pubmed: 21533116
Cereb Cortex. 2018 Apr 1;28(4):1141-1153
pubmed: 28184409
Front Neurosci. 2016 Nov 10;10:484
pubmed: 27891068
PLoS One. 2013 Dec 17;8(12):e84241
pubmed: 24358348
Sci Rep. 2018 Jul 3;8(1):10024
pubmed: 29968786
J Neurosci Methods. 2014 Jan 15;221:175-82
pubmed: 24140478
J Neurosci. 2017 Aug 23;37(34):8092-8101
pubmed: 28716961
J Cogn Neurosci. 2007 Jul;19(7):1081-8
pubmed: 17583985
J Cereb Blood Flow Metab. 2017 Jul;37(7):2368-2382
pubmed: 27596833
Nat Methods. 2019 Jan;16(1):111-116
pubmed: 30532080
Cereb Cortex. 2016 Dec;26(12):4497-4512
pubmed: 27797832
Nat Neurosci. 2017 Feb 23;20(3):299-303
pubmed: 28230846
Neuroimage. 2008 Aug 1;42(1):60-9
pubmed: 18502665
Neuroimage. 2016 Nov 15;142:544-552
pubmed: 27520750
Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11603-11608
pubmed: 27671662
Pain. 2018 Apr;159(4):719-727
pubmed: 29319607
Neuroimage. 2014 Nov 15;102 Pt 2:838-47
pubmed: 25175535
Neuroimage. 2018 Oct 15;180(Pt B):463-484
pubmed: 29454935
Curr Opin Neurol. 2008 Aug;21(4):424-30
pubmed: 18607202
J Neurosci. 2014 Oct 15;34(42):13963-75
pubmed: 25319693
Curr Opin Pharmacol. 2013 Oct;13(5):813-20
pubmed: 23856429
Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9673-8
pubmed: 15976020
Front Neuroinform. 2014 Apr 28;8:44
pubmed: 24817849
J Neurosci Methods. 2016 Dec 1;274:38-48
pubmed: 27702586
Cereb Cortex. 2018 Jul 1;28(7):2495-2506
pubmed: 29901787
Magn Reson Med. 1995 Oct;34(4):537-41
pubmed: 8524021
Sci Rep. 2018 Jul 12;8(1):10591
pubmed: 30002419
J Comp Neurol. 2009 Apr 10;513(5):532-41
pubmed: 19226510
Comput Biomed Res. 1996 Jun;29(3):162-73
pubmed: 8812068
Curr Biol. 2019 Jul 22;29(14):2295-2306.e5
pubmed: 31303490
J Neurosci Methods. 2013 Apr 15;214(2):144-8
pubmed: 23376497
Magn Reson Med. 2014 Oct;72(4):1103-12
pubmed: 24285608
Sci Rep. 2016 Nov 29;6:37802
pubmed: 27898057
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7900-5
pubmed: 27357684
Neuroimage. 2016 Jan 15;125:571-577
pubmed: 26520769
Sci Rep. 2017 Dec 1;7(1):16742
pubmed: 29196686
Neuroimage. 2017 Feb 1;146:1-18
pubmed: 27845252
Neuroimage. 2017 Dec;163:419-436
pubmed: 28942060
Front Pharmacol. 2015 Oct 21;6:231
pubmed: 26539115
Brain Connect. 2011;1(1):13-36
pubmed: 22432952
PLoS One. 2011;6(11):e27839
pubmed: 22125628
Front Neural Circuits. 2017 Feb 03;11:5
pubmed: 28217085
Neuropsychobiology. 2014;69(4):187-201
pubmed: 24863537
Neuroimage. 2014 Feb 15;87:403-15
pubmed: 24080504
Neuroimage. 2016 Jul 1;134:1-11
pubmed: 27033685
Neuroimage. 2017 May 15;152:497-508
pubmed: 28315459
Neurosci Biobehav Rev. 2014 Sep;45:100-18
pubmed: 24875392
Sci Adv. 2015 Nov 20;1(10):e1500775
pubmed: 26702437
Neuroimage. 2011 Feb 1;54(3):2033-44
pubmed: 20851191
Nature. 2014 Apr 10;508(7495):207-14
pubmed: 24695228
Brain. 2018 Jul 1;141(7):2055-2065
pubmed: 29722793
Neurobiol Dis. 2016 Nov;95:35-45
pubmed: 27404940
Neuroimage. 2013 Oct 15;80:349-59
pubmed: 23571418
Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7209-14
pubmed: 19357304
Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18745-50
pubmed: 25512496
Front Neurosci. 2015 Aug 05;9:269
pubmed: 26300718
Neuroimage. 2016 Jan 1;124(Pt A):442-454
pubmed: 26163799
J Neurosci. 2009 Jan 28;29(4):1191-201
pubmed: 19176827
Cereb Cortex. 2017 Oct 1;27(10):5014-5023
pubmed: 28922833
Nat Rev Neurosci. 2007 Sep;8(9):700-11
pubmed: 17704812
Brain Struct Funct. 2016 Jul;221(6):3067-79
pubmed: 26195064
Neuroimage. 2015 Jul 15;115:281-91
pubmed: 25913701
Neuroimage. 2015 Apr 1;109:151-9
pubmed: 25583611
Ann N Y Acad Sci. 2008 Mar;1124:1-38
pubmed: 18400922
Brain Struct Funct. 2016 Mar;221(2):941-54
pubmed: 25445840
Nat Neurosci. 2014 Mar;17(3):400-6
pubmed: 24487234

Auteurs

Joanes Grandjean (J)

Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, 138667, Singapore. Electronic address: Joanes.Grandjean@radboudumc.nl.

Carola Canella (C)

Functional Neuroimaging Laboratory, Istituto Italiano di Tecnologia, Centre for Neuroscience and Cognitive Systems @ UNITN, 38068, Rovereto, Italy; CIMeC, Centre for Mind/Brain Sciences, University of Trento, 38068, Rovereto, Italy.

Cynthia Anckaerts (C)

Bio-Imaging Lab, University of Antwerp, CDE, Universiteitsplein 1, 2610, Antwerp, Belgium.

Gülebru Ayrancı (G)

Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.

Salma Bougacha (S)

Commissariat à l'Énergie Atomique et Aux Énergies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, Fontenay-aux-roses, France; Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud, Université Paris-Saclay UMR 9199, Neurodegenerative Diseases Laboratory, Fontenay-aux-Roses, France.

Thomas Bienert (T)

Department of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Killianstr. 5a, 79106, Freiburg, Germany; BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Georges-Köhler-Allee 80, 79110, Freiburg, Germany.

David Buehlmann (D)

Institute for Biomedical Engineering, University and ETH Zürich, Wolfgang-Pauli-Str. 27, 8093, Zürich, Switzerland.

Ludovico Coletta (L)

Functional Neuroimaging Laboratory, Istituto Italiano di Tecnologia, Centre for Neuroscience and Cognitive Systems @ UNITN, 38068, Rovereto, Italy; CIMeC, Centre for Mind/Brain Sciences, University of Trento, 38068, Rovereto, Italy.

Daniel Gallino (D)

Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.

Natalia Gass (N)

Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Clément M Garin (CM)

Commissariat à l'Énergie Atomique et Aux Énergies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, Fontenay-aux-roses, France; Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud, Université Paris-Saclay UMR 9199, Neurodegenerative Diseases Laboratory, Fontenay-aux-Roses, France.

Nachiket Abhay Nadkarni (NA)

Commissariat à l'Énergie Atomique et Aux Énergies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, Fontenay-aux-roses, France; Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud, Université Paris-Saclay UMR 9199, Neurodegenerative Diseases Laboratory, Fontenay-aux-Roses, France.

Neele S Hübner (NS)

Department of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Killianstr. 5a, 79106, Freiburg, Germany; BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Georges-Köhler-Allee 80, 79110, Freiburg, Germany.

Meltem Karatas (M)

Department of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Killianstr. 5a, 79106, Freiburg, Germany; The Engineering Science, Computer Science and Imaging Laboratory (ICube), Department of Biophysics and Nuclear Medicine, University of Strasbourg and University Hospital of Strasbourg, 67000, Strasbourg, France.

Yuji Komaki (Y)

Central Institute for Experimental Animals (CIEA), 3-25-12, Tonomachi, Kawasaki, Kanagawa, 210-0821, Japan; Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.

Silke Kreitz (S)

Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Fahrstraße 17, 91054, Erlangen, Germany.

Francesca Mandino (F)

Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, 138667, Singapore; Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.

Anna E Mechling (AE)

Department of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Killianstr. 5a, 79106, Freiburg, Germany; BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Georges-Köhler-Allee 80, 79110, Freiburg, Germany.

Chika Sato (C)

Functional and Molecular Imaging Team, Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Anagawa 4-9-1, Inage, Chiba-city, Chiba, 263-8555, Japan.

Katja Sauer (K)

Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Fahrstraße 17, 91054, Erlangen, Germany.

Disha Shah (D)

Bio-Imaging Lab, University of Antwerp, CDE, Universiteitsplein 1, 2610, Antwerp, Belgium; Laboratory for the Research of Neurodegenerative Diseases, VIB Center for Brain and Disease Research, KU Leuven, O&N4 Herestraat 49 Box 602, 3000, Leuven, Belgium.

Sandra Strobelt (S)

Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Fahrstraße 17, 91054, Erlangen, Germany.

Norio Takata (N)

Central Institute for Experimental Animals (CIEA), 3-25-12, Tonomachi, Kawasaki, Kanagawa, 210-0821, Japan; Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan.

Isabel Wank (I)

Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Fahrstraße 17, 91054, Erlangen, Germany.

Tong Wu (T)

Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia; Centre for Medical Image Computing, Department of Computer Science, & Max Planck University College London Centre for Computational Psychiatry and Ageing Research, University College London, London, UK; Computational, Cognitive and Clinical Imaging Lab, Division of Brain Sciences, Department of Medicine, Imperial College London, W12 0NN, UK; UK DRI Centre for Care Research and Technology, Imperial College London, W12 0NN, UK.

Noriaki Yahata (N)

Functional and Molecular Imaging Team, Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Anagawa 4-9-1, Inage, Chiba-city, Chiba, 263-8555, Japan.

Ling Yun Yeow (LY)

Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, 138667, Singapore.

Yohan Yee (Y)

Hospital for Sick Children and Department of Medical Biophysics, The University of Toronto, Toronto, Ontario, Canada.

Ichio Aoki (I)

Functional and Molecular Imaging Team, Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Anagawa 4-9-1, Inage, Chiba-city, Chiba, 263-8555, Japan.

M Mallar Chakravarty (MM)

Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada; Department of Psychiatry, McGill University, Montreal, Quebec, Canada; Department of Biological and Biomedical Engineering, McGill University, Montreal, Quebec, Canada.

Wei-Tang Chang (WT)

Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, 138667, Singapore.

Marc Dhenain (M)

Commissariat à l'Énergie Atomique et Aux Énergies Alternatives (CEA), Direction de la Recherche Fondamentale (DRF), Institut François Jacob, MIRCen, Fontenay-aux-roses, France; Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud, Université Paris-Saclay UMR 9199, Neurodegenerative Diseases Laboratory, Fontenay-aux-Roses, France.

Dominik von Elverfeldt (D)

Department of Radiology, Medical Physics, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Killianstr. 5a, 79106, Freiburg, Germany; BrainLinks-BrainTools Cluster of Excellence, University of Freiburg, Georges-Köhler-Allee 80, 79110, Freiburg, Germany.

Laura-Adela Harsan (LA)

The Engineering Science, Computer Science and Imaging Laboratory (ICube), Department of Biophysics and Nuclear Medicine, University of Strasbourg and University Hospital of Strasbourg, 67000, Strasbourg, France.

Andreas Hess (A)

Institute of Experimental and Clinical Pharmacology and Toxicology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Fahrstraße 17, 91054, Erlangen, Germany.

Tianzi Jiang (T)

Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia; Brainnetome Center & National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.

Georgios A Keliris (GA)

Bio-Imaging Lab, University of Antwerp, CDE, Universiteitsplein 1, 2610, Antwerp, Belgium.

Jason P Lerch (JP)

Hospital for Sick Children and Department of Medical Biophysics, The University of Toronto, Toronto, Ontario, Canada; Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, OX3 9DU, UK.

Andreas Meyer-Lindenberg (A)

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Germany.

Hideyuki Okano (H)

Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan; Laboratory for Marmoset Neural Architecture, RIKEN Brain Science Institute, Wako, Saitama, 351-0198, Japan.

Markus Rudin (M)

Institute for Biomedical Engineering, University and ETH Zürich, Wolfgang-Pauli-Str. 27, 8093, Zürich, Switzerland; Institute of Pharmacology and Toxicology, University of Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland; Neuroscience Center Zürich, ETH Zürich and University of Zürich, Zürich, Switzerland.

Alexander Sartorius (A)

Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Annemie Van der Linden (A)

Bio-Imaging Lab, University of Antwerp, CDE, Universiteitsplein 1, 2610, Antwerp, Belgium.

Marleen Verhoye (M)

Bio-Imaging Lab, University of Antwerp, CDE, Universiteitsplein 1, 2610, Antwerp, Belgium.

Wolfgang Weber-Fahr (W)

Department of Neuroimaging, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.

Nicole Wenderoth (N)

Neural Control of Movement Lab, Department of Health Sciences and Technology, ETH Zürich, Winterthurerstrasse 190, 8057, Zurich, Switzerland; Neuroscience Center Zürich, ETH Zürich and University of Zürich, Zürich, Switzerland.

Valerio Zerbi (V)

Neural Control of Movement Lab, Department of Health Sciences and Technology, ETH Zürich, Winterthurerstrasse 190, 8057, Zurich, Switzerland; Neuroscience Center Zürich, ETH Zürich and University of Zürich, Zürich, Switzerland.

Alessandro Gozzi (A)

Functional Neuroimaging Laboratory, Istituto Italiano di Tecnologia, Centre for Neuroscience and Cognitive Systems @ UNITN, 38068, Rovereto, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Common functional networks in the mouse brain...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Common functional networks in the mouse brain...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroimagerie fonctionnelle › Cartographie cérébrale › Connectome › Common functional networks in the mouse brain...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Traitement d'image par ordinateur › Common functional networks in the mouse brain...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Common functional networks in the mouse brain...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Common functional networks in the mouse brain...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Common functional networks in the mouse brain...
questionsmedicales.fr › Système nerveux › Réseau nerveux › Common functional networks in the mouse brain...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Reproductibilité des résultats › Common functional networks in the mouse brain...