Novel triazole-tetrahydroisoquinoline hybrids as human aromatase inhibitors.

Aromatase Inhibitors / chemical synthesis Cell Line, Tumor Drug Screening Assays, Antitumor Humans Hydrogen Bonding Inhibitory Concentration 50 Molecular Docking Simulation Spectrum Analysis / methods Structure-Activity Relationship Tetrahydroisoquinolines / chemistry Triazoles / chemistry
Aromatase inhibitor Isoquinoline Molecular docking Sulfonamide Synthesis Triazole

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
12 2019
Historique:
received: 23 04 2019
revised: 14 08 2019
accepted: 27 09 2019
pubmed: 16 10 2019
medline: 21 10 2020
entrez: 16 10 2019
Statut: ppublish

Résumé

Novel thirteen triazole-tetrahydroisoquinoline derivatives (2a-m) were synthesized and evaluated for their aromatase inhibitory activities. Seven triazoles showed significant aromatase inhibitory activity (IC

Identifiants

DOI: 10.1016/j.bioorg.2019.103327 PMID: 31614285
pubmed: 31614285
pii: S0045-2068(19)30632-7
doi: 10.1016/j.bioorg.2019.103327
pii:
doi:

Substances chimiques

Aromatase Inhibitors 0
Tetrahydroisoquinolines 0
Triazoles 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103327

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Chanamon Chamduang (C)

Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand.

Ratchanok Pingaew (R)

Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand. Electronic address: ratchanok@swu.ac.th.

Veda Prachayasittikul (V)

Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand. Electronic address: veda.pra@mahidol.ac.th.

Supaluk Prachayasittikul (S)

Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.

Somsak Ruchirawat (S)

Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, and Program in Chemical Biology, Chulabhorn Graduate Institute, Bangkok 10210, Thailand; Center of Excellence on Environmental Health and Toxicology, Commission on Higher, Education (CHE), Ministry of Education, Thailand.

Virapong Prachayasittikul (V)

Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Antihormones › Inhibiteurs de la synthèse des stéroïdes › Inhibiteurs de l'aromatase › Novel triazole-tetrahydroisoquinoline hybrids...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Novel triazole-tetrahydroisoquinoline hybrids...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de criblage d'agents antitumoraux › Novel triazole-tetrahydroisoquinoline hybrids...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Novel triazole-tetrahydroisoquinoline hybrids...
questionsmedicales.fr › Phénomènes chimiques › Liaison hydrogène › Novel triazole-tetrahydroisoquinoline hybrids...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Concentration inhibitrice 50 › Novel triazole-tetrahydroisoquinoline hybrids...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Novel triazole-tetrahydroisoquinoline hybrids...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Novel triazole-tetrahydroisoquinoline hybrids...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Novel triazole-tetrahydroisoquinoline hybrids...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoquinoléines › Tétrahydroisoquinoléines › Novel triazole-tetrahydroisoquinoline hybrids...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Triazoles › Novel triazole-tetrahydroisoquinoline hybrids...