Identification and Characterization of Post-activated B Cells in Systemic Autoimmune Diseases.

Agammaglobulinaemia Tyrosine Kinase / immunology Autoimmune Diseases / immunology B-Lymphocytes / immunology Humans Protein Tyrosine Phosphatases / immunology Receptors, Antigen, B-Cell / immunology Syk Kinase / immunology
B cell receptor signaling CD40 anergy post-activation primary Sjögren's syndrome rheumatoid arthritis systemic lupus erythematosus toll-like receptor 9

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2019
Historique:
received: 30 04 2019
accepted: 27 08 2019
entrez: 17 10 2019
pubmed: 17 10 2019
medline: 11 11 2020
Statut: epublish

Résumé

Autoimmune diseases (AID) such as systemic lupus erythematosus (SLE), primary Sjögren's syndrome (pSS), and rheumatoid arthritis (RA) are chronic inflammatory diseases in which abnormalities of B cell function play a central role. Although it is widely accepted that autoimmune B cells are hyperactive

Identifiants

DOI: 10.3389/fimmu.2019.02136 PMID: 31616406 PMC: PMC6768969
pubmed: 31616406
doi: 10.3389/fimmu.2019.02136
pmc: PMC6768969
doi:

Substances chimiques

Receptors, Antigen, B-Cell 0
Agammaglobulinaemia Tyrosine Kinase EC 2.7.10.2
Syk Kinase EC 2.7.10.2
Protein Tyrosine Phosphatases EC 3.1.3.48

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2136

Informations de copyright

Copyright © 2019 Weißenberg, Szelinski, Schrezenmeier, Stefanski, Wiedemann, Rincon-Arevalo, Welle, Jungmann, Nordström, Walter, Imgenberg-Kreuz, Nordmark, Rönnblom, Bachali, Catalina, Grammer, Lipsky, Lino and Dörner.

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Auteurs

Sarah Y Weißenberg (SY)

Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany.
German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany.

Franziska Szelinski (F)

Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany.
German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany.

Eva Schrezenmeier (E)

Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany.

Ana-Luisa Stefanski (AL)

Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany.

Annika Wiedemann (A)

Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany.

Hector Rincon-Arevalo (H)

Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany.
German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany.
Grupo de Inmunología Celular e Inmunogenética, Facultad de Medicina, Instituto de Investigaciones Médicas, Universidad de Antioquia UdeA, Medellín, Colombia.

Anna Welle (A)

Department of Genetics and Epigenetics, Saarland University, Saarbrücken, Germany.

Annemarie Jungmann (A)

Department of Genetics and Epigenetics, Saarland University, Saarbrücken, Germany.

Karl Nordström (K)

Department of Genetics and Epigenetics, Saarland University, Saarbrücken, Germany.

Jörn Walter (J)

Department of Genetics and Epigenetics, Saarland University, Saarbrücken, Germany.

Juliana Imgenberg-Kreuz (J)

Department of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Gunnel Nordmark (G)

Department of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Lars Rönnblom (L)

Department of Medical Sciences, Rheumatology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Prathyusha Bachali (P)

RILITE Research Institute, Charlottesville, VA, United States.

Michelle D Catalina (MD)

RILITE Research Institute, Charlottesville, VA, United States.

Amrie C Grammer (AC)

RILITE Research Institute, Charlottesville, VA, United States.

Peter E Lipsky (PE)

RILITE Research Institute, Charlottesville, VA, United States.

Andreia C Lino (AC)

Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany.
German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany.

Thomas Dörner (T)

Department of Rheumatology and Clinical Immunology, Charité University Medicine Berlin, Berlin, Germany.
German Rheumatism Research Center Berlin (DRFZ), Berlin, Germany.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Agammaglobulinaemia tyrosine kinase › Identification and Characterization of...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Identification and Characterization of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Identification and Characterization of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification and Characterization of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein Tyrosine Phosphatases › Identification and Characterization of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs pour l'antigène des lymphocytes B › Identification and Characterization of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Syk kinase › Identification and Characterization of...