Comparison of three common whole blood platelet function tests for in vitro P2Y12 induced platelet inhibition.
Blood Coagulation
/ drug effects
Comparative Effectiveness Research
Drug Monitoring
/ methods
Healthy Volunteers
Humans
Platelet Aggregation Inhibitors
/ pharmacology
Platelet Function Tests
/ instrumentation
Point-of-Care Testing
Purinergic P2Y Receptor Antagonists
/ pharmacology
Ticagrelor
/ pharmacology
Coagulation
Diagnostic
Platelet function
Platelets
TEG®
Journal
Journal of thrombosis and thrombolysis
ISSN: 1573-742X
Titre abrégé: J Thromb Thrombolysis
Pays: Netherlands
ID NLM: 9502018
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
pubmed:
18
10
2019
medline:
10
4
2021
entrez:
18
10
2019
Statut:
ppublish
Résumé
In the context of interventional cardiology, platelet function testing may identify patients treated with P2Y12-inhibitors at an increased risk of mortality, thrombosis and bleeding. Several whole blood point-of-care platelet function analyzers are available; however, inter-device differences have not been examined systematically. To compare three platelet function tests under standardized in vitro conditions. Healthy volunteer (n = 10) blood samples were spiked with increasing concentrations of ticagrelor (0-7500 ng/mL) and/or ASA (0-3280 ng/mL), measured on three platelet function analyzers (TEG
Identifiants
pubmed: 31620937
doi: 10.1007/s11239-019-01971-1
pii: 10.1007/s11239-019-01971-1
pmc: PMC7293977
doi:
Substances chimiques
Platelet Aggregation Inhibitors
0
Purinergic P2Y Receptor Antagonists
0
Ticagrelor
GLH0314RVC
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
135-143Références
Neumann FJ, Sousa-Uva M, Ahlsson A et al (2019) 2018 ESC/EACTS Guidelines on myocardial revascularization. EuroIntervention 14(14):1435–1534
doi: 10.4244/EIJY19M01_01
Wallentin L, Becker RC, Budaj A et al (2009) Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 361(11):1045–1057
doi: 10.1056/NEJMoa0904327
Aradi D, Kirtane A, Bonello L et al (2015) Bleeding and stent thrombosis on P2Y12-inhibitors: collaborative analysis on the role of platelet reactivity for risk stratification after percutaneous coronary intervention. Eur Heart J 36(27):1762–1771
doi: 10.1093/eurheartj/ehv104
Tantry US, Bonello L, Aradi D et al (2013) Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding. J Am Coll Cardiol 62(24):2261–2273
doi: 10.1016/j.jacc.2013.07.101
Sibbing D, Aradi D, Jacobshagen C et al (2017) Guided de-escalation of antiplatelet treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention (TROPICAL-ACS): a randomised, open-label, multicentre trial. Lancet 390(10104):1747–1757
doi: 10.1016/S0140-6736(17)32155-4
Malm CJ, Hansson EC, Akesson J et al (2016) Preoperative platelet function predicts perioperative bleeding complications in ticagrelor-treated cardiac surgery patients: a prospective observational study. Br J Anaesth 117(3):309–315
doi: 10.1093/bja/aew189
Gurbel PA, Bliden KP, Guyer K et al (2005) Platelet reactivity in patients and recurrent events post-stenting: results of the PREPARE POST-STENTING Study. J Am Coll Cardiol 46(10):1820–1826
doi: 10.1016/j.jacc.2005.07.041
Gurbel PA, Bliden KP, Navickas IA et al (2010) Adenosine diphosphate-induced platelet-fibrin clot strength: a new thrombelastographic indicator of long-term poststenting ischemic events. Am Heart J 160(2):346–354
doi: 10.1016/j.ahj.2010.05.034
Mahla E, Suarez TA, Bliden KP et al (2012) Platelet function measurement-based strategy to reduce bleeding and waiting time in clopidogrel-treated patients undergoing coronary artery bypass graft surgery: the timing based on platelet function strategy to reduce clopidogrel-associated bleeding related to CABG (TARGET-CABG) study. Circ Cardiovasc Interv 5(2):261–269
doi: 10.1161/CIRCINTERVENTIONS.111.967208
Sivapalan P, Back AC, Ostrowski SR, Ravn HB, Johansson PI (2017) Transfusion requirements in elective cardiopulmonary bypass surgery patients: predictive value of Multiplate and Thromboelastography (TEG) Platelet Mapping Assay. Scand J Clin Lab Invest 77(5):345–351
doi: 10.1080/00365513.2017.1325000
Dias JD, Sauaia A, Achneck HE, Hartmann J, Moore EE (2019) Thromboelastography-guided therapy improves patient blood management and certain clinical outcomes in elective cardiac and liver surgery and emergency resusCitation: a systematic review and analysis. J Thromb Haemost 17:984–994
doi: 10.1111/jth.14447
Kasivisvanathan R, Abbassi-Ghadi N, Kumar S et al (2014) Risk of bleeding and adverse outcomes predicted by thromboelastography platelet mapping in patients taking clopidogrel within 7 days of non-cardiac surgery. Br J Surg 101(11):1383–1390
doi: 10.1002/bjs.9592
Dias JD, Lopez-Espina CG, Ippolito J (2019) Rapid point-of-care detection and classification of direct-acting oral anticoagulants (DOACs) with the TEG(R) 6s: implications for trauma and acute care surgery. J Trauma Acute Care Surg 87:364–370
doi: 10.1097/TA.0000000000002357
Ranucci M, Baryshnikova E, Soro G et al (2011) Multiple electrode whole-blood aggregometry and bleeding in cardiac surgery patients receiving thienopyridines. Ann Thorac Surg 91(1):123–129
doi: 10.1016/j.athoracsur.2010.09.022
Sibbing D, Braun S, Morath T et al (2009) Platelet reactivity after clopidogrel treatment assessed with point-of-care analysis and early drug-eluting stent thrombosis. J Am Coll Cardiol 53(10):849–856
doi: 10.1016/j.jacc.2008.11.030
Sibbing D, Steinhubl SR, Schulz S, Schomig A, Kastrati A (2010) Platelet aggregation and its association with stent thrombosis and bleeding in clopidogrel-treated patients: initial evidence of a therapeutic window. J Am Coll Cardiol 56(4):317–318
doi: 10.1016/j.jacc.2010.03.048
Breet NJ, van Werkum JW, Bouman HJ et al (2011) High on-treatment platelet reactivity to both aspirin and clopidogrel is associated with the highest risk of adverse events following percutaneous coronary intervention. Heart 97(12):983–990
doi: 10.1136/hrt.2010.220491
Price MJ, Endemann S, Gollapudi RR et al (2008) Prognostic significance of post-clopidogrel platelet reactivity assessed by a point-of-care assay on thrombotic events after drug-eluting stent implantation. Eur Heart J 29(8):992–1000
doi: 10.1093/eurheartj/ehn046
Paniccia R, Priora R, Liotta AA, Abbate R (2015) Platelet function tests: a comparative review. Vasc Health Risk Manag 11:133–148
doi: 10.2147/VHRM.S44469
Gurbel PA, Bliden KP, Tantry US et al (2016) First report of the point-of-care TEG: a technical validation study of the TEG-6S system. Platelets 27(7):642–649
doi: 10.3109/09537104.2016.1153617
Hartmann J, Mason D, Achneck H (2018) Thromboelastography (TEG) point-of-care diagnostic for hemostasis management. Point Care 17(1):15–22
Ramiz S, Hartmann J (2019) Clinical utility of viscoelastic testing (TEG and ROTEM analyzers) in the management of old and new therapies for hemophilia. Am J Hematol 94(2):249–256
pubmed: 30328141
Gremmel T, Steiner S, Seidinger D et al (2009) Comparison of methods to evaluate clopidogrel-mediated platelet inhibition after percutaneous intervention with stent implantation. Thromb Haemost 101(2):333–339
doi: 10.1160/TH08-09-0577
Paniccia R, Antonucci E, Maggini N et al (2009) Assessment of platelet function on whole blood by multiple electrode aggregometry in high-risk patients with coronary artery disease receiving antiplatelet therapy. Am J Clin Pathol 131(6):834–842
doi: 10.1309/AJCPTE3K1SGAPOIZ
Sibbing D, Braun S, Jawansky S et al (2008) Assessment of ADP-induced platelet aggregation with light transmission aggregometry and multiple electrode platelet aggregometry before and after clopidogrel treatment. Thromb Haemost 99(1):121–126
doi: 10.1160/TH07-07-0478
Smith JW, Steinhubl SR, Lincoff AM et al (1999) Rapid platelet-function assay: an automated and quantitative cartridge-based method. Circulation 99(5):620–625
doi: 10.1161/01.CIR.99.5.620
Jakubowski JA, Payne CD, Li YG et al (2008) The use of the VerifyNow P2Y12 point-of-care device to monitor platelet function across a range of P2Y12 inhibition levels following prasugrel and clopidogrel administration. Thromb Haemost 99(2):409–415
doi: 10.1160/TH07-09-0575
Paniccia R, Antonucci E, Gori AM et al (2007) Different methodologies for evaluating the effect of clopidogrel on platelet function in high-risk coronary artery disease patients. J Thromb Haemost 5(9):1839–1847
doi: 10.1111/j.1538-7836.2007.02656.x
Cayla G, Cuisset T, Silvain J et al (2016) Platelet function monitoring to adjust antiplatelet therapy in elderly patients stented for an acute coronary syndrome (ANTARCTIC): an open-label, blinded-endpoint, randomised controlled superiority trial. Lancet 388(10055):2015–2022
doi: 10.1016/S0140-6736(16)31323-X
Collet JP, Cuisset T, Range G et al (2012) Bedside monitoring to adjust antiplatelet therapy for coronary stenting. N Engl J Med 367(22):2100–2109
doi: 10.1056/NEJMoa1209979
Siller-Matula JM, Jilma B (2013) Why have studies of tailored anti-platelet therapy failed so far? Thromb Haemost 110(4):628–631
pubmed: 23884166
Khanna V, Hobson A, Mikael R et al (2014) Does the VerifyNow P2Y12 assay overestimate "therapeutic response" to clopidogrel? Insights using short thrombelastography. Thromb Haemost 111(6):1150–1159
doi: 10.1160/TH13-10-0856
Danielak D, Komosa A, Tomczak A et al (2017) Determinants of high on-treatment platelet reactivity and agreement between VerifyNow and Multiplate assays. Scand J Clin Lab Invest 77(3):190–198
doi: 10.1080/00365513.2017.1286686
Collyer T, Gray D, Sandhu R, Berridge J, Lyons G (2009) Assessment of platelet inhibition secondary to clopidogrel and aspirin therapy in preoperative acute surgical patients measured by Thrombelastography
doi: 10.1093/bja/aep039
Can MM, Tanboga IH, Turkyilmaz E et al (2010) The risk of false results in the assessment of platelet function in the absence of antiplatelet medication: comparison of the PFA-100, multiplate electrical impedance aggregometry and verify now assays. Thromb Res 125(4):e132–e137
doi: 10.1016/j.thromres.2009.11.005
Penz SM, Bernlochner I, Toth O et al (2010) Selective and rapid monitoring of dual platelet inhibition by aspirin and P2Y12 antagonists by using multiple electrode aggregometry. Thromb J 8:9
doi: 10.1186/1477-9560-8-9
Ko YG, Suh JW, Kim BH et al (2011) Comparison of 2 point-of-care platelet function tests, VerifyNow Assay and Multiple Electrode Platelet Aggregometry, for predicting early clinical outcomes in patients undergoing percutaneous coronary intervention. Am Heart J 161(2):383–390
doi: 10.1016/j.ahj.2010.10.036
Larsen PD, Holley AS, Sasse A et al (2017) Comparison of Multiplate and VerifyNow platelet function tests in predicting clinical outcome in patients with acute coronary syndromes. Thromb Res 152:14–19
doi: 10.1016/j.thromres.2017.02.006
Calmette L, Martin AC, Le Bonniec B et al (2017) Ticagrelor reversal: in vitro assessment of four haemostatic agents. J Clin Pathol 70(9):733–739
doi: 10.1136/jclinpath-2016-204117