Curcumin Activates the Nrf2 Pathway and Induces Cellular Protection Against Oxidative Injury.
Animals
Anti-Inflammatory Agents
/ pharmacology
Antineoplastic Agents, Phytogenic
/ pharmacology
Antioxidants
/ pharmacology
Apoptosis
/ drug effects
Biological Availability
Cardiotonic Agents
/ pharmacology
CpG Islands
/ drug effects
Curcumin
/ chemistry
DNA Methylation
/ drug effects
Humans
Hypoglycemic Agents
/ pharmacology
Kelch-Like ECH-Associated Protein 1
/ antagonists & inhibitors
Kidney
/ drug effects
Liver
/ drug effects
Lung
/ drug effects
Mice
Molecular Structure
Muscle, Skeletal
/ drug effects
NF-E2-Related Factor 2
/ agonists
Neuroprotective Agents
/ pharmacology
Oxidative Stress
/ drug effects
Phytotherapy
Radiation-Protective Agents
/ pharmacology
Retinal Pigment Epithelium
/ drug effects
Signal Transduction
/ drug effects
Curcumin
cancer
nuclear factor erythroid 2-related factor 2
oxidative stress
therapeutic effects.
Journal
Current molecular medicine
ISSN: 1875-5666
Titre abrégé: Curr Mol Med
Pays: Netherlands
ID NLM: 101093076
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
07
2019
revised:
11
09
2019
accepted:
18
09
2019
pubmed:
18
10
2019
medline:
11
6
2021
entrez:
18
10
2019
Statut:
ppublish
Résumé
Curcumin is a naturally occurring polyphenol that is isolated from the rhizome of Curcuma longa (turmeric). This medicinal compound has different biological activities, including antioxidant, antibacterial, antineoplastic, and anti-inflammatory. It also has therapeutic effects on neurodegenerative disorders, renal disorders, and diabetes mellitus. Curcumin is safe and well-tolerated at high concentrations without inducing toxicity. It seems that curcumin is capable of targeting the Nrf2 signaling pathway in protecting the cells against oxidative damage. Besides, this strategy is advantageous in cancer therapy. Accumulating data demonstrates that curcumin applies four distinct ways to stimulate the Nrf2 signaling pathway, including inhibition of Keap1, affecting the upstream mediators of Nrf2, influencing the expression of Nrf2 and target genes, and finally, improving the nuclear translocation of Nrf2. In the present review, the effects of curcumin on the Nrf2 signaling pathway to exert its therapeutic and biological activities has been discussed.
Identifiants
pubmed: 31622191
pii: CMM-EPUB-101541
doi: 10.2174/1566524019666191016150757
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Antineoplastic Agents, Phytogenic
0
Antioxidants
0
Cardiotonic Agents
0
Hypoglycemic Agents
0
KEAP1 protein, human
0
Kelch-Like ECH-Associated Protein 1
0
NF-E2-Related Factor 2
0
NFE2L2 protein, human
0
Neuroprotective Agents
0
Nfe2l2 protein, mouse
0
Radiation-Protective Agents
0
Curcumin
IT942ZTH98
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
116-133Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.