Altered hypothalamic metabolism in early multiple sclerosis - MR spectroscopy study.

Adult Aspartic Acid / metabolism Choline / metabolism Creatine / metabolism Female Glutamic Acid / metabolism Glutamine / metabolism Humans Hypothalamus / diagnostic imaging Inositol / metabolism Magnetic Resonance Spectroscopy Male Multiple Sclerosis / diagnostic imaging Young Adult
(1)H MRS Glutamate excitotoxicity Hypothalamus Multiple sclerosis

Journal

Journal of the neurological sciences
ISSN: 1878-5883
Titre abrégé: J Neurol Sci
Pays: Netherlands
ID NLM: 0375403

Informations de publication

Date de publication:
15 Dec 2019
Historique:
received: 10 01 2019
revised: 19 08 2019
accepted: 10 09 2019
pubmed: 18 10 2019
medline: 17 9 2020
entrez: 18 10 2019
Statut: ppublish

Résumé

Multiple sclerosis (MS) is a disease characterized by overlapping processes of neuroinflammation and neuro-axonal degeneration. Disturbances of the hypothalamo-pituitary axis in MS are supposed to modulate neuroinflammatory circuits, however, there is insufficient knowledge about the hypothalamic metabolism alterations in early MS. This

Identifiants

DOI: 10.1016/j.jns.2019.116458 PMID: 31622679
pubmed: 31622679
pii: S0022-510X(19)30390-9
doi: 10.1016/j.jns.2019.116458
pii:
doi:

Substances chimiques

Glutamine 0RH81L854J
Aspartic Acid 30KYC7MIAI
Glutamic Acid 3KX376GY7L
Inositol 4L6452S749
Creatine MU72812GK0
Choline N91BDP6H0X

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

116458

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Petra Hnilicová (P)

Biomedical Center Martin - Division of Neurosciences, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia. Electronic address: petra.hnilicova@jfmed.uniba.sk.

Ema Kantorová (E)

Clinic of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.

Hubert Poláček (H)

Clinic of Nuclear Medicine, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.

Marián Grendár (M)

Biomedical Center Martin - Bioinformatic unit, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.

Michal Bittšanský (M)

Biomedical Center Martin - Division of Neurosciences, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.

Daniel Čierny (D)

Department of Clinical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.

Štefan Sivák (Š)

Clinic of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.

Kamil Zeleňák (K)

Clinic of Radiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.

Ján Lehotský (J)

Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.

Dušan Dobrota (D)

Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.

Egon Kurča (E)

Clinic of Neurology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Altered hypothalamic metabolism in early...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide aspartique › Altered hypothalamic metabolism in early...
questionsmedicales.fr › Composés chimiques organiques › Composés onium › Composés d'ammonium quaternaire › Choline › Altered hypothalamic metabolism in early...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Créatine › Altered hypothalamic metabolism in early...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide glutamique › Altered hypothalamic metabolism in early...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés neutres › Glutamine › Altered hypothalamic metabolism in early...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Altered hypothalamic metabolism in early...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Hypothalamus › Altered hypothalamic metabolism in early...
questionsmedicales.fr › Glucides › Polyols › Inositol › Altered hypothalamic metabolism in early...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Altered hypothalamic metabolism in early...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Altered hypothalamic metabolism in early...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Altered hypothalamic metabolism in early...