Association between impulsivity and neural activation to alcohol cues in heavy drinkers.
Alcohol
Cue reactivity
Delay discounting
FMRI
Impulsivity
Sensation seeking
Journal
Psychiatry research. Neuroimaging
ISSN: 1872-7506
Titre abrégé: Psychiatry Res Neuroimaging
Pays: Netherlands
ID NLM: 101723001
Informations de publication
Date de publication:
30 11 2019
30 11 2019
Historique:
received:
15
07
2019
revised:
16
09
2019
accepted:
23
09
2019
pubmed:
18
10
2019
medline:
9
4
2020
entrez:
18
10
2019
Statut:
ppublish
Résumé
This study examines associations between two measures of impulsivity and brain response to alcohol taste cues. Impulsivity is both a risk factor for and a consequence of alcohol use and misuse. Frontostriatal circuits are linked to both impulsivity and addiction-related behaviors, including response to alcohol cues. Non-treatment-seeking heavy drinkers (n = 55) completed (i) an fMRI alcohol taste cue-reactivity paradigm; (ii) the monetary choice questionnaire (MCQ), a measure of choice impulsivity where participants choose between smaller, sooner rewards and larger, delayed rewards; (iii) and the UPPS-P Impulsive Behavior Scale, a self-report measure assessing five impulsivity factors. General linear models identified associations between neural alcohol taste cue-reactivity and impulsivity, adjusting for age, gender, and smoking status. Self-reported sensation seeking was positively associated with alcohol taste cue-elicited activation in frontostriatal regions, such that individuals who reported higher sensation seeking displayed greater neural response to alcohol taste cues. Conversely, delay discounting was negatively associated with activation in frontoparietal regions, such that individuals who reported greater discounting showed less cue-elicited activation. There were no significant associations between other self-reported impulsivity subscales and alcohol taste cue-reactivity. These results indicate that sensation seeking is associated with reward responsivity, while delay discounting is associated with recruitment of self-control circuitry.
Identifiants
pubmed: 31622796
pii: S0925-4927(19)30197-0
doi: 10.1016/j.pscychresns.2019.110986
pmc: PMC7238761
mid: NIHMS1588322
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
110986Subventions
Organisme : NIAAA NIH HHS
ID : F32 AA027699
Pays : United States
Organisme : NIAAA NIH HHS
ID : R21 AA023669
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA024635
Pays : United States
Informations de copyright
Copyright © 2019. Published by Elsevier B.V.
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