Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorder.
Adolescent
Adult
Attention Deficit Disorder with Hyperactivity
/ genetics
Autism Spectrum Disorder
/ genetics
Case-Control Studies
DNA Copy Number Variations
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Iceland
Male
Norway
Polymorphism, Single Nucleotide
Schizophrenia
/ genetics
Journal
Translational psychiatry
ISSN: 2158-3188
Titre abrégé: Transl Psychiatry
Pays: United States
ID NLM: 101562664
Informations de publication
Date de publication:
17 10 2019
17 10 2019
Historique:
received:
17
01
2019
accepted:
30
07
2019
revised:
12
07
2019
entrez:
19
10
2019
pubmed:
19
10
2019
medline:
4
9
2020
Statut:
epublish
Résumé
Attention-deficit/hyperactivity disorder (ADHD) is a highly heritable common childhood-onset neurodevelopmental disorder. Some rare copy number variations (CNVs) affect multiple neurodevelopmental disorders such as intellectual disability, autism spectrum disorders (ASD), schizophrenia and ADHD. The aim of this study is to determine to what extent ADHD shares high risk CNV alleles with schizophrenia and ASD. We compiled 19 neuropsychiatric CNVs and test 14, with sufficient power, for association with ADHD in Icelandic and Norwegian samples. Eight associate with ADHD; deletions at 2p16.3 (NRXN1), 15q11.2, 15q13.3 (BP4 & BP4.5-BP5) and 22q11.21, and duplications at 1q21.1 distal, 16p11.2 proximal, 16p13.11 and 22q11.21. Six of the CNVs have not been associated with ADHD before. As a group, the 19 CNVs associate with ADHD (OR = 2.43, P = 1.6 × 10
Identifiants
pubmed: 31624239
doi: 10.1038/s41398-019-0599-y
pii: 10.1038/s41398-019-0599-y
pmc: PMC6797719
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
258Références
Biol Psychiatry. 2005 Jun 1;57(11):1313-23
pubmed: 15950004
Nat Genet. 2017 Jan;49(1):27-35
pubmed: 27869829
Int J Epidemiol. 2006 Oct;35(5):1146-50
pubmed: 16926217
Nat Genet. 2019 Mar;51(3):431-444
pubmed: 30804558
Nat Genet. 2015 Mar;47(3):291-5
pubmed: 25642630
J Hum Genet. 2011 Jul;56(7):541-4
pubmed: 21614007
Dev Sci. 2005 Mar;8(2):132-40
pubmed: 15720371
Eur Child Adolesc Psychiatry. 2010 Mar;19(3):281-95
pubmed: 20148275
PLoS One. 2013 Apr 18;8(4):e61365
pubmed: 23637818
Genome Res. 2007 Nov;17(11):1665-74
pubmed: 17921354
Genet Med. 2016 Apr;18(4):341-9
pubmed: 26066539
Curr Psychiatry Rep. 2017 Sep 20;19(11):82
pubmed: 28929285
J Med Genet. 2009 Jun;46(6):382-8
pubmed: 19289393
Eur J Hum Genet. 2000 Oct;8(10):739-42
pubmed: 11039572
Mol Autism. 2016 May 06;7:27
pubmed: 27158440
Genome Med. 2014 Apr 28;6(4):29
pubmed: 24944580
J Atten Disord. 2010 Sep;14(2):121-31
pubmed: 19805623
Am J Med Genet B Neuropsychiatr Genet. 2013 Jul;162B(5):419-430
pubmed: 23728934
J Mol Psychiatry. 2013 Apr 23;1(1):4
pubmed: 25408897
Am J Hum Genet. 2014 May 1;94(5):677-94
pubmed: 24768552
Br J Psychiatry. 2013 Aug;203(2):103-6
pubmed: 23703314
Genet Med. 2016 Nov;18(11):1111-1118
pubmed: 26963284
Behav Brain Funct. 2008 Feb 19;4:10
pubmed: 18284679
J Am Acad Child Adolesc Psychiatry. 2014 Jul;53(7):761-70.e26
pubmed: 24954825
Cell. 2012 Mar 16;148(6):1223-41
pubmed: 22424231
Nature. 2014 Jan 16;505(7483):361-6
pubmed: 24352232
Nat Genet. 2019 Jan;51(1):63-75
pubmed: 30478444
Pediatrics. 2011 Aug;128(2):364-73
pubmed: 21768324
JAMA Psychiatry. 2017 Mar 1;74(3):282-290
pubmed: 28114601
Lancet. 2010 Oct 23;376(9750):1401-8
pubmed: 20888040
Genet Med. 2015 Feb;17(2):149-57
pubmed: 25077648
BMC Psychiatry. 2017 Jan 17;17(1):23
pubmed: 28095819
Mol Psychiatry. 2019 Apr;24(4):562-575
pubmed: 29892054
Am J Med Genet B Neuropsychiatr Genet. 2017 Jun;174(4):367-380
pubmed: 28349640
Am J Psychiatry. 2014 Jun;171(6):627-39
pubmed: 24577245
Mol Psychiatry. 2014 Jan;19(1):37-40
pubmed: 24217254
Sci Transl Med. 2011 Aug 10;3(95):95ra75
pubmed: 21832240
Int J Epidemiol. 2016 Apr;45(2):382-8
pubmed: 27063603
Br J Psychiatry. 2019 May;214(5):297-304
pubmed: 30767844
Hum Mol Genet. 2009 Mar 1;18(5):988-96
pubmed: 18945720
Eur Neuropsychopharmacol. 2018 Oct;28(10):1059-1088
pubmed: 30195575
Transl Psychiatry. 2017 Apr 25;7(4):e1109
pubmed: 28440815
Br J Psychiatry. 2013 Aug;203(2):107-11
pubmed: 23703318
Expert Rev Neurother. 2016;16(2):145-56
pubmed: 26651394
J Med Genet. 2010 May;47(5):332-41
pubmed: 19914906
J Atten Disord. 2009 Sep;13(2):175-87
pubmed: 19372500
Int J Mol Sci. 2015 Feb 13;16(2):4068-82
pubmed: 25689425
Am J Psychiatry. 2012 Feb;169(2):195-204
pubmed: 22420048
J Am Acad Child Adolesc Psychiatry. 2016 Jun;55(6):521-3
pubmed: 27238071