Autonomic effects induced by pharmacological activation and inhibition of Raphe Pallidus neurons in anaesthetized adult pigs.
Age Factors
Animals
Autonomic Agents
/ pharmacology
Female
GABA Antagonists
/ administration & dosage
GABA-A Receptor Agonists
/ administration & dosage
Heart Rate
/ drug effects
Microinjections
/ methods
Neurons
/ drug effects
Nucleus Raphe Pallidus
/ drug effects
Pyridazines
/ administration & dosage
Shivering
/ drug effects
Swine
Raphe Pallidus
autonomic nervous system
gabazine
hypothermia
pig
synthetic torpor
Journal
Clinical and experimental pharmacology & physiology
ISSN: 1440-1681
Titre abrégé: Clin Exp Pharmacol Physiol
Pays: Australia
ID NLM: 0425076
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
11
01
2019
revised:
18
09
2019
accepted:
09
10
2019
pubmed:
19
10
2019
medline:
8
5
2021
entrez:
19
10
2019
Statut:
ppublish
Résumé
The Raphe Pallidus (RPa) is a region of the brainstem that was shown to modulate the sympathetic outflow to many tissues and organs involved in thermoregulation and energy expenditure. In rodents, the pharmacological activation of RPa neurons was shown to increase the activity of the brown adipose tissue, heart rate, and expired CO
Identifiants
pubmed: 31625617
doi: 10.1111/1440-1681.13194
doi:
Substances chimiques
Autonomic Agents
0
GABA Antagonists
0
GABA-A Receptor Agonists
0
Pyridazines
0
gabazine
99460MG420
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
281-285Informations de copyright
© 2019 John Wiley & Sons Australia, Ltd.
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