Analysis of 5000 year-old human teeth using optimized large-scale and targeted proteomics approaches for detection of sex-specific peptides.
Amelogenin
Data dependent acquisition
Paleoproteomics
Parallel reaction monitoring
Sex determination
Tooth
Journal
Journal of proteomics
ISSN: 1876-7737
Titre abrégé: J Proteomics
Pays: Netherlands
ID NLM: 101475056
Informations de publication
Date de publication:
16 01 2020
16 01 2020
Historique:
received:
24
01
2019
revised:
30
08
2019
accepted:
07
10
2019
pubmed:
19
10
2019
medline:
22
6
2021
entrez:
19
10
2019
Statut:
ppublish
Résumé
The study demonstrates the high potential of MS-based proteomics coupled to an iterative database search strategy for the in-depth investigation of ancient proteomes. An efficient targeted PRM MS-based approach, although limited to the detection of a single pair of sex-specific amelogenin peptides, allowed confirming the sex of individuals in ancient dental remains, an essential information for paleoanthropologists facing the issue of sex determination and dimorphism.
Identifiants
pubmed: 31626997
pii: S1874-3919(19)30320-3
doi: 10.1016/j.jprot.2019.103548
pii:
doi:
Substances chimiques
Amelogenin
0
Peptides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103548Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.