Comparison of calcineurin inhibitors in combination with conventional methotrexate, reduced methotrexate, or mycophenolate mofetil for prophylaxis of graft-versus-host disease after umbilical cord blood transplantation.
Adolescent
Adult
Aged
Aged, 80 and over
Calcineurin Inhibitors
/ administration & dosage
Cord Blood Stem Cell Transplantation
/ adverse effects
Dose-Response Relationship, Drug
Drug Therapy, Combination
Female
Graft Survival
Graft vs Host Disease
/ epidemiology
Hematologic Neoplasms
/ therapy
Humans
Immunosuppressive Agents
/ administration & dosage
Incidence
Infections
/ epidemiology
Japan
/ epidemiology
Kaplan-Meier Estimate
Leukocyte Count
Male
Methotrexate
/ administration & dosage
Middle Aged
Mycophenolic Acid
/ administration & dosage
Neutrophils
Platelet Count
Retrospective Studies
Treatment Outcome
Young Adult
GVHD
MMF
Methotrexate
Prophylaxis
Reduced-dose
UCBT
Journal
Annals of hematology
ISSN: 1432-0584
Titre abrégé: Ann Hematol
Pays: Germany
ID NLM: 9107334
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
11
05
2019
accepted:
11
09
2019
pubmed:
20
10
2019
medline:
18
12
2019
entrez:
20
10
2019
Statut:
ppublish
Résumé
Umbilical cord blood transplantation (UCBT) is a curative treatment for hematological malignancies. However, appropriate prophylaxis against graft-versus-host disease (GVHD), aimed at obtaining rapid and stable engraftment and avoiding toxicity, remains controversial in UCBT. We retrospectively compared outcomes in 409 patients who received calcineurin inhibitors (CIs) plus conventional-dose methotrexate (conv-MTX/CIs, n = 77; methotrexate, 10 mg/m
Identifiants
pubmed: 31628517
doi: 10.1007/s00277-019-03801-z
pii: 10.1007/s00277-019-03801-z
doi:
Substances chimiques
Calcineurin Inhibitors
0
Immunosuppressive Agents
0
Mycophenolic Acid
HU9DX48N0T
Methotrexate
YL5FZ2Y5U1
Types de publication
Comparative Study
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM