Influenza A Virus Hemagglutinin-Neuraminidase-Receptor Balance: Preserving Virus Motility.
hemagglutinin
influenza A virus
mucus
neuraminidase
receptor
sialic acid
Journal
Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
29
05
2019
revised:
29
08
2019
accepted:
30
08
2019
pubmed:
21
10
2019
medline:
8
6
2021
entrez:
21
10
2019
Statut:
ppublish
Résumé
Influenza A viruses (IAVs) occasionally cross the species barrier and adapt to novel host species. This requires readjustment of the functional balance of the sialic acid receptor-binding hemagglutinin (HA) and the receptor-destroying neuraminidase (NA) to the sialoglycan-receptor repertoire of the new host. Novel techniques have revealed mechanistic details of this HA-NA-receptor balance, emphasizing a previously underappreciated crucial role for NA in driving the motility of receptor-associated IAV particles. Motility enables virion penetration of the sialylated mucus layer as well as attachment to, and uptake into, underlying epithelial cells. As IAVs are essentially irreversibly bound in the absence of NA activity, the fine-tuning of the HA-NA-receptor balance rather than the binding avidity of IAV particles per se is an important factor in determining host species tropism.
Identifiants
pubmed: 31629602
pii: S0966-842X(19)30235-5
doi: 10.1016/j.tim.2019.08.010
pmc: PMC7172302
pii:
doi:
Substances chimiques
Hemagglutinin Glycoproteins, Influenza Virus
0
Hemagglutinins, Viral
0
Receptors, Virus
0
Viral Proteins
0
Neuraminidase
EC 3.2.1.18
N-Acetylneuraminic Acid
GZP2782OP0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
57-67Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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