TREK-1 and TRAAK Are Principal K
action potential
conduction velocity
leak K(+) currents
myelinated nerve
node of Ranvier
saltatory conduction
sensory
temperature
two-pore-domain K(+) channels
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
04 12 2019
04 12 2019
Historique:
received:
19
03
2019
revised:
30
07
2019
accepted:
27
08
2019
pubmed:
22
10
2019
medline:
24
3
2020
entrez:
22
10
2019
Statut:
ppublish
Résumé
Rapid conduction of nerve impulses is critical in life and relies on action potential (AP) leaps through the nodes of Ranvier (NRs) along myelinated nerves. While NRs are the only sites where APs can be regenerated during nerve conduction on myelinated nerves, ion channel mechanisms underlying the regeneration and conduction of APs at mammalian NRs remain incompletely understood. Here, we show that TREK-1 and TRAAK, the thermosensitive and mechanosensitive two-pore-domain potassium (K2P) channels, are clustered at NRs of rat trigeminal Aβ-afferent nerves with a density over 3,000-fold higher than that on their somas. These K2P channels, but not voltage-gated K
Identifiants
pubmed: 31630908
pii: S0896-6273(19)30773-1
doi: 10.1016/j.neuron.2019.08.042
pmc: PMC6895425
mid: NIHMS1539172
pii:
doi:
Substances chimiques
Kcnk4 protein, rat
0
Potassium Channels
0
Potassium Channels, Tandem Pore Domain
0
potassium channel protein TREK-1
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
960-971.e7Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE018661
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE023090
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS109059
Pays : United States
Organisme : NIEHS NIH HHS
ID : U01 ES026458
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.
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